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    Home/Medications/Spironolactone

    Potassium-Sparing Diuretics

    Spironolactone

    Spironolactone (generic Aldactone) is a potassium-sparing diuretic used for heart failure, high blood pressure, fluid retention and hormone-related conditions, and widely prescribed off-label for hormonal acne. It is an inexpensive generic.

    Written by the Script Unlock editorial teamLast updated September 29, 2026Not yet reviewed by an independent pharmacist

    This page is general information about a medication and how cash prices for it are set. It is not medical advice and does not replace the label, your prescriber or your pharmacist. How we handle medical information

    Get cash quotes for Spironolactone
    Brand names
    Aldactone, CaroSpir
    Generic available in the US
    Yes
    Dosage forms
    Tablet; Oral suspension (CaroSpir)
    Strengths on US labels
    25, 50 and 100 mg tablets
    Commonly prescribed for
    Heart Failure, High Blood Pressure, Edema, PCOS, Acne, Hirsutism

    Tablets are generic from many manufacturers. The suspension is a brand product and is not interchangeable milligram for milligram with tablets.

    About Spironolactone

    Spironolactone blocks aldosterone, a hormone that makes the kidneys retain sodium and water and lose potassium. Blocking it removes fluid while keeping potassium, and at higher doses it also blocks androgen receptors, which is why it is used for hormonal acne and hirsutism in women and as part of some hormone therapy regimens.

    In heart failure it reduces hospitalisations and deaths at low doses. It is also used for resistant high blood pressure, for fluid from liver disease, and for primary hyperaldosteronism. Because it raises potassium, blood tests are checked after starting and with any dose change, and potassium supplements or salt substitutes are usually avoided.

    Breast tenderness or enlargement, menstrual changes and, in men, gynaecomastia are the recognizable side effects. It carries a warning based on tumor findings in rodents at high doses, which is why prescribers use the lowest effective dose.

    Why the cash price for Spironolactone differs from pharmacy to pharmacy

    Spironolactone tablets are a commodity generic; the cash price is fee and margin. Acne prescriptions often use higher doses and more tablets per month, so the per-tablet mark-up matters more than the dispensing fee for those patients.

    Some pharmacies stock only the 25 mg tablet; a prescription for 100 mg filled as four 25 mg tablets costs more than one 100 mg tablet where the larger strength is stocked.

    Have a Spironolactone prescription?

    Upload it and licensed pharmacies reply with their own cash price. You pay the pharmacy, not us.

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    Ways to pay less for Spironolactone without insurance

    • Ask the pharmacy whether it stocks the strength on your prescription, and ask the prescriber to write the strength that minimizes tablet count.
    • Ask for a ninety-day prescription.
    • Ask whether spironolactone is on the pharmacy’s flat-price generic list.
    • Compare independent and mail-order pharmacies.
    • Upload your prescription to Script Unlock so licensed pharmacies can quote their cash price. You pay the pharmacy directly.

    How Script Unlock gets you a cash price for Spironolactone

    Prices on this site come from pharmacies responding to a real prescription. We do not publish estimated, average or "typical" prices, because none of those would be your price.

    1. 1You upload your prescription

      A photo of your Spironolactone prescription is enough. Nothing is sold on the site; you are asking pharmacies to quote.

    2. 2Licensed pharmacies respond

      Pharmacies that Script Unlock has verified see the request and each can reply with its own cash price for your exact drug, strength and quantity.

    3. 3You choose and pay the pharmacy

      You compare the responses, pick a pharmacy, and pay that pharmacy directly when you collect. Script Unlock never takes a patient payment and never sets the price.

    Upload a Spironolactone prescriptionWhat Script Unlock cannot do

    Questions to ask your pharmacist about Spironolactone

    1. 1.Should I avoid potassium supplements or salt substitutes?
    2. 2.When will my potassium and kidney function be checked?
    3. 3.What should I do if I feel light-headed?
    4. 4.Can I take it with my other blood pressure medicines?
    5. 5.Which over-the-counter painkillers should I avoid?

    Where Spironolactone fits

    • Condition: High Blood Pressure
    • Condition: Hair Loss
    • Condition: Acne
    • Drug class: Diuretics (Water Pills)

    Related medications

    FurosemideCarvedilolLisinoprilHydrochlorothiazide

    Sources

    • FDA-approved labeling on DailyMed (spironolactone)
    • FDA Orange Book (approved generics and therapeutic equivalence)
    • MedlinePlus drug information (National Library of Medicine)

    Script Unlock is a marketplace that lets licensed pharmacies quote a cash price on your prescription. It does not prescribe, dispense or sell medication, does not process patient payments, and does not give medical advice. Always follow the instructions of your prescriber and pharmacist and read the medication guide supplied with your medicine.

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    Upload your prescription and licensed, verified pharmacies each quote their own cash price. You pay the pharmacy directly.

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