Dermatological

    Clobetasol Propionate

    Clobetasol propionate is a super-high-potency steroid for psoriasis, eczema and other inflamed, itchy skin and scalp conditions. Every standard form, from cream to foam, spray and shampoo, is generic, so the form on the prescription mainly sets the cash price, and all forms are for short courses.

    Written by the Script Unlock editorial teamLast updated October 7, 2026Not yet reviewed by an independent pharmacist

    This page is general information about a medication and how cash prices for it are set. It is not medical advice and does not replace the label, your prescriber or your pharmacist. How we handle medical information

    Brand names
    Clovate, Temovate, Dermovate, Clobex, Olux, Impoyz
    Generic available in the US
    Yes
    Dosage forms
    Cream and emollient cream; Ointment; Gel; Scalp solution; Foam; Lotion; Spray; Shampoo
    Strengths on US labels
    0.5 mg per gram or per mL in all standard forms; 0.25 mg per gram in Impoyz cream
    Commonly prescribed for
    Severe inflammatory skin conditions, Psoriasis, Eczema

    Every standard form has generics from more than one maker; Impoyz, a lower-strength cream for psoriasis, is a brand with an authorized generic.

    About Clobetasol Propionate

    Clobetasol is among the strongest topical corticosteroids; its labels call it super-high potency. It eases inflammation, itching and redness in steroid-responsive conditions such as psoriasis and eczema. The cream, ointment, gel and lotion treat the skin, the solution and shampoo the scalp, the foam the scalp and body, and the spray plaque psoriasis.

    Most forms are used for no more than two weeks in a row; the lotion and spray allow up to four weeks for psoriasis patches that have not cleared, and the shampoo four weeks. Use is capped at 50 grams a week (50 mL of scalp solution). The skin forms are kept off the face, groin and underarms and are not used for rosacea or perioral dermatitis. The cream, ointment, gel, solution and foam are not recommended under 12; the lotion, spray and shampoo are for adults.

    Burning, stinging and itching are the usual side effects. Heavier or longer use can thin the skin and cause stretch marks, acne-like bumps or paler patches, and topical steroids can raise the risk of cataracts and glaucoma. Clobetasol suppressed the adrenal glands at the lowest doses tested, and Cushing’s syndrome has been reported in infants and adults after prolonged use.

    Taking Clobetasol Propionate

    How to take it
    Apply a thin layer and rub it in gently, usually twice a day, then wash your hands. Put the shampoo on dry scalp once a day, leave it 15 minutes, then lather with water and rinse well. Hold the foam can upside down and do not dispense it onto warm hands. Do not cover treated skin, and stop when the condition is controlled.
    If you miss a dose
    Apply it when you remember, unless the next application is nearly due; then skip the missed one. Do not apply extra to make up.
    Storage
    At room temperature, tightly closed; do not freeze it or refrigerate the gel or ointment. Keep the foam and spray, which are flammable, and the solution away from heat and open flame, and do not smoke while applying them.
    Interactions to know about
    No drug interactions are listed, but other steroid creams or tablets add to the total absorbed, which can raise blood sugar. Ask before putting other skin products on the treated area, and report blurred vision or signs of skin infection.

    This summarizes the official prescribing information. Your prescriber’s and pharmacist’s instructions, and the leaflet that comes with your medicine, take priority.

    Why the cash price for Clobetasol Propionate differs from pharmacy to pharmacy

    The cream, ointment and scalp solution each have many generic makers, so quotes differ mostly by mark-up and package size. The gel, foam, lotion, spray and shampoo have fewer makers, so quotes vary more, and the foam, spray and shampoo generally cost more. The pharmacist cannot switch the form on a prescription without the prescriber.

    Have a Clobetasol Propionate prescription?

    Upload it and licensed pharmacies reply with their own cash price. You pay the pharmacy, not us.

    Get quotes

    Ways to pay less for Clobetasol Propionate without insurance

    • Ask the prescriber whether a cream or ointment, or the solution for the scalp, would work as well for you as a foam, spray or shampoo.
    • Ask for the quantity the course needs; with a two-week limit for most forms, a large tube may go partly unused.
    • If Impoyz is prescribed, ask whether the pharmacy carries its authorized generic.
    • Upload the prescription to Script Unlock so licensed pharmacies can quote their cash price. You pay the pharmacy directly.

    How Script Unlock gets you a cash price for Clobetasol Propionate

    Prices on this site come from pharmacies responding to a real prescription. We do not publish estimated, average or "typical" prices, because none of those would be your price.

    1. 1You upload your prescription

      A photo of your Clobetasol Propionate prescription is enough. Nothing is sold on the site; you are asking pharmacies to quote.

    2. 2Licensed pharmacies respond

      Pharmacies that Script Unlock has verified see the request and each can reply with its own cash price for your exact drug, strength and quantity.

    3. 3You choose and pay the pharmacy

      You compare the responses, pick a pharmacy, and pay that pharmacy directly when you collect. Script Unlock never takes a patient payment and never sets the price.

    Questions to ask your pharmacist about Clobetasol Propionate

    1. 1.How many weeks can I use this form, and how much is too much in a week?
    2. 2.Which parts of my body should I keep it away from?
    3. 3.Can I use moisturizers or other products on the same area?
    4. 4.What signs of thinning skin or infection should I watch for?

    Sources

    Script Unlock is a marketplace that lets licensed pharmacies quote a cash price on your prescription. It does not prescribe, dispense or sell medication, does not process patient payments, and does not give medical advice. Always follow the instructions of your prescriber and pharmacist and read the medication guide supplied with your medicine.