Dermatological

    Permethrin

    Permethrin kills mites and lice. The 5 percent cream (Elimite and generics) is a prescription treatment for scabies, and the 1 percent lotion (Nix Lice Killing Creme Rinse) treats head lice without a prescription; both are labeled from 2 months of age. One application of the cream is generally curative, and itching that continues afterward is not by itself a reason to treat again.

    Written by the Script Unlock editorial teamLast updated October 9, 2026Not yet reviewed by an independent pharmacist

    This page is general information about a medication and how cash prices for it are set. It is not medical advice and does not replace the label, your prescriber or your pharmacist. How we handle medical information

    Brand names
    Elimite, Nix
    Generic available in the US
    Yes
    Dosage forms
    Cream (prescription); Lotion, sold as a creme rinse (over the counter)
    Strengths on US labels
    5 percent (50 mg per gram) cream in a 60 g tube; 1 percent lotion (creme rinse), 280 mg per fluid ounce, in a 2 fluid ounce (59 mL) bottle
    Commonly prescribed for
    Scabies, Head Lice

    Elimite is still listed, and generic 5 percent creams from a few makers are rated equivalent to it; one older generic has been discontinued. The 1 percent lotion (creme rinse) is sold over the counter as Nix Lice Killing Creme Rinse and in store-brand versions.

    About Permethrin

    For scabies, the cream is massaged into the skin from the head to the soles of the feet, about 30 g for an average adult, and washed off in a bath or shower after 8 to 14 hours. Adults rarely have mites on the scalp, but infants are treated on the scalp, temples and forehead as well, and MedlinePlus adds adults over 65. One application is generally curative, and it is repeated only if living mites are found 14 days later. For head lice, the 1 percent lotion goes on hair that has been shampooed without conditioner and towel dried, saturating the hair and scalp; it stays on for 10 minutes, no longer, and is rinsed out with warm water, and MedlinePlus says to repeat the treatment if live lice are seen seven or more days later.

    Anyone allergic to permethrin, to any other synthetic pyrethroid or to pyrethrins must not use the cream, and the Nix label says to ask a doctor first if you are allergic to ragweed. Burning, stinging and itching are the most common effects of the cream, and redness, numbness, tingling and rash can occur. Scabies itself causes itching, swelling and redness, which may get worse for a while after treatment, so persistent itching alone is not a reason to treat again. Both products are kept out of the eyes; the lice product is not used inside the nose, ears, mouth or vagina or on eyebrows or eyelashes, and it is stopped if breathing trouble, eye irritation or continuing skin irritation develops.

    In pregnancy, the cream label advises use only if clearly needed, and because it is not known whether permethrin passes into breast milk, it suggests a nursing mother may pause breastfeeding or not use the cream. MedlinePlus also lists household steps: recently used clothing, towels and bedding are washed in very hot water or dry cleaned, combs and brushes are washed in hot water, family members are checked for lice, and sexual partners are treated for scabies. Elimite (Aurobindo) remains listed in the Orange Book with generic 5 percent creams rated equivalent to it, and one older generic is listed as discontinued. Nix Lice Killing Creme Rinse is sold over the counter under its own FDA approval and comes with a nit comb.

    Taking Permethrin

    How to take it
    Scabies: massage the cream thoroughly into the skin from head to soles, keeping it out of the eyes, and wash it off after 8 to 14 hours. Head lice: shampoo without conditioner, towel dry, shake the lotion, protect the eyes with a washcloth or towel, saturate the hair and scalp, leave it 10 minutes, rinse with warm water in a sink rather than a shower or tub, then comb out lice and nits.
    If you miss a dose
    It is a one-time treatment, repeated only when the label or prescriber says: for scabies if living mites are seen 14 days later, and for lice if live lice are seen seven or more days later.
    Storage
    At room temperature in the closed original container, away from heat and moisture, out of reach of children. Use a take-back program rather than flushing.
    Interactions to know about
    Tell the prescriber about allergies to permethrin, pyrethrins or ragweed, other medicines and skin products you use, and pregnancy or breastfeeding. Stop the lice product and see a doctor for trouble breathing, eye irritation, or skin or scalp irritation that continues or becomes infected.

    This summarizes the official prescribing information. Your prescriber’s and pharmacist’s instructions, and the leaflet that comes with your medicine, take priority.

    Why the cash price for Permethrin differs from pharmacy to pharmacy

    Generic 5 percent cream rated equivalent to Elimite comes from a few makers, so a prescription that allows substitution can be filled with whichever one the pharmacy stocks, while one that names Elimite and blocks substitution is priced as a brand.

    The cream comes in a 60 g tube, and about 30 g treats an average adult, so the number of tubes written for a household or a repeat application drives the total. The lice creme rinse is sold over the counter.

    Have a Permethrin prescription?

    Upload it and licensed pharmacies reply with their own cash price. You pay the pharmacy, not us.

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    Ways to pay less for Permethrin without insurance

    • Ask for the generic 5 percent cream, and check that the prescription allows substitution rather than naming Elimite only.
    • Ask the prescriber to write the number of tubes the whole treatment needs, since one 60 g tube may cover two average adults or a repeat application.
    • For head lice in anyone 2 months or older, ask the pharmacist about permethrin 1 percent lotion (creme rinse) sold over the counter, and check that permethrin is the active ingredient, since other lice products contain different ones.
    • Compare more than one pharmacy for the cream.
    • Upload the prescription to Script Unlock so licensed pharmacies can quote their cash price. You pay the pharmacy directly.

    How Script Unlock gets you a cash price for Permethrin

    Prices on this site come from pharmacies responding to a real prescription. We do not publish estimated, average or "typical" prices, because none of those would be your price.

    1. 1You upload your prescription

      A photo of your Permethrin prescription is enough. Nothing is sold on the site; you are asking pharmacies to quote.

    2. 2Licensed pharmacies respond

      Pharmacies that Script Unlock has verified see the request and each can reply with its own cash price for your exact drug, strength and quantity.

    3. 3You choose and pay the pharmacy

      You compare the responses, pick a pharmacy, and pay that pharmacy directly when you collect. Script Unlock never takes a patient payment and never sets the price.

    Questions to ask your pharmacist about Permethrin

    1. 1.How much cream do I need, and should everyone in my household be treated at the same time?
    2. 2.How long do I leave it on, and when do I wash it off?
    3. 3.Is my child old enough for this product?
    4. 4.What should I do if my itching continues after treatment?

    Sources

    Script Unlock is a marketplace that lets licensed pharmacies quote a cash price on your prescription. It does not prescribe, dispense or sell medication, does not process patient payments, and does not give medical advice. Always follow the instructions of your prescriber and pharmacist and read the medication guide supplied with your medicine.