Oxycodone/AcetaminophenOxycodone Hydrochloride and Acetaminophen

About Oxycodone/Acetaminophen

Oxycodone acts on opioid receptors in the brain and spinal cord, and acetaminophen adds pain relief that works differently. The label approves it for pain severe enough to need an opioid when other treatments are inadequate, at the lowest effective dose for the shortest time; its safety and effectiveness in children have not been established. The 2.5 mg tablet is taken as one or two tablets every 6 hours as needed and the stronger ones as one tablet, with a daily limit of 12 tablets of the 2.5 or 5 mg strength, 8 of the 7.5 mg and 6 of the 10 mg; Prolate and Nalocet, with 300 mg of acetaminophen, have the same limits.

The boxed warnings cover addiction even at prescribed doses; slowed or stopped breathing, most likely at the start or after a dose increase; fatal overdose if a child swallows one dose; coma or death with benzodiazepines, alcohol or other sedatives; newborn withdrawal after long use in pregnancy; overdose when a medicine that blocks the enzyme CYP3A4 is added, or one that speeds it up is stopped; and the Opioid Analgesic REMS. Another covers the liver: acetaminophen has caused acute liver failure, at times fatal or needing a transplant, mostly above 4,000 mg a day. It is not used with significant breathing problems, acute or severe asthma without monitoring, or a blocked bowel. Lightheadedness, dizziness, drowsiness, nausea and vomiting are most common, and it is stopped at the first sign of a rash.

It cannot be refilled. Under the REMS, pharmacies can request prepaid mail-back envelopes for unused medicine, and prescribers are asked to discuss naloxone or nalmefene; naloxone 4 mg nasal spray is sold without a prescription. Under 2025 FDA labeling changes, the Percocet label (revised December 2025) stresses that higher doses carry more risk and lists gabapentin and pregabalin among the sedatives that deepen its effects; after regular use it is tapered, not stopped suddenly. The liquids carry one more boxed warning: confusing milligrams with milliliters can cause a fatal overdose. In November 2025 the FDA drug shortage database posted Endo’s discontinuation of Endocet and of the 2.5 mg Percocet tablet.

Taking Oxycodone/Acetaminophen

How to take it

As prescribed, usually every 6 hours as needed, within your strength’s daily tablet limit and 4,000 mg of acetaminophen a day from all products. Measure the liquid in milliliters with a marked oral syringe or measuring cup, never a household spoon.

If you miss a dose

If your prescriber has you take it regularly rather than as needed, MedlinePlus says to take a missed dose unless the next is almost due, then skip it; never take a double dose.

Storage

At room temperature, protected from moisture, where children and others cannot reach it. Use a take-back program or ask the pharmacy for a prepaid mail-back envelope; if no take-back option is readily available, the label says to flush unused medicine.

Interactions to know about

Avoid other products containing acetaminophen. Benzodiazepines, sleep medicines, gabapentin, pregabalin, alcohol and other sedatives add to its effect on breathing. Erythromycin, ketoconazole and ritonavir raise oxycodone levels, as can stopping rifampin, carbamazepine or phenytoin; serotonin-affecting antidepressants can cause serotonin syndrome, and MAO inhibitors are not taken within 14 days.

This summarizes the official prescribing information. Your prescriber’s and pharmacist’s instructions, and the leaflet that comes with your medicine, take priority.

Why the cash price for Oxycodone/Acetaminophen differs from pharmacy to pharmacy

The 5, 7.5 and 10 mg tablets with 325 mg of acetaminophen have many makers, so quotes differ mainly by fee and markup, unless the prescription names Percocet and blocks substitution, which prices it as a brand. The 2.5 mg tablet, the 300 mg tablets and the liquids have fewer makers and may need to be ordered, and a 300 mg tablet cannot be swapped for a 325 mg one without the prescriber.

Schedule II stock is ordered on a special DEA form from wholesalers that must flag unusual orders and may set their own ordering thresholds, so a pharmacy short of stock may fill only part of a prescription or decline it.

Ways to pay less for Oxycodone/Acetaminophen without insurance

• Ask for a generic, and make sure the prescription allows substitution rather than naming Percocet only.
• If Prolate, Nalocet or a liquid is prescribed, ask the prescriber whether a generic 325 mg tablet would suit you.
• Confirm stock before the prescription is sent, since an unfilled electronic prescription can be transferred only once.
• Ask for a partial fill if you may not need every tablet; where state law allows, the rest can be collected within 30 days of the date written.
• Upload the prescription to Script Unlock so licensed pharmacies can quote their cash price. You pay the pharmacy directly.

Questions to ask your pharmacist about Oxycodone/Acetaminophen

1. 1.How much acetaminophen am I taking a day at this dose?
2. 2.Which of my other medicines contain acetaminophen?
3. 3.Is my strength in stock, and can you fill the full quantity?
4. 4.Can I buy naloxone here, and how do I get rid of tablets I do not use?

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