Weight Loss Medications
Wegovy vs Zepbound
Compare the two leading FDA-approved weight loss medications: Wegovy (semaglutide) vs Zepbound (tirzepatide).
Head-to-Head Comparison
| Category | Semaglutide | Tirzepatide |
|---|---|---|
Effectiveness | Average 15-17% body weight loss | Average 20-25% body weight loss |
Cost | $1,300-$1,500/month | $1,000-$1,100/month |
| Side Effects | Common GI side effects | Similar GI side effects, possibly higher rates |
Convenience | Longer track record, more availability | Newer, potential supply issues |
| Insurance Coverage | Limited weight loss coverage | Limited weight loss coverage |
Key Differences
- Zepbound (tirzepatide) is a dual GIP/GLP-1 agonist
- Wegovy (semaglutide) is a GLP-1 agonist only
- Zepbound shows greater weight loss in head-to-head studies
- Wegovy has longer safety data available
Similarities
- Both FDA-approved for chronic weight management
- Both are once-weekly injectables
- Both require BMI criteria for prescription
- Similar side effect profiles (GI-focused)
Which Is Best For You?
Semaglutide is Best For:
- Patients preferring longer safety track record
- Those tolerating semaglutide well
- When Zepbound unavailable
Tirzepatide is Best For:
- Patients seeking maximum weight loss
- Those who plateaued on semaglutide
- When cost is a factor
Frequently Asked Questions
Which medication produces more weight loss?
Head-to-head trials show Zepbound (tirzepatide) produces about 5-7% more body weight loss than Wegovy (semaglutide) on average.
Is Zepbound safer than Wegovy?
Both have similar safety profiles. Zepbound is newer so has less long-term data, but clinical trials show comparable safety.
Compare Prices for Semaglutide and Tirzepatide
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