Prescription Drug Prices in Colorado
7.5% of Colorado residents are uninsured — that's 437,925 people. Prescription prices vary by up to 10× between pharmacies in Colorado. Here's how to pay less.
Why Prescription Prices Vary So Much in Colorado
Unlike most goods, prescription drug prices in Colorado are not regulated or standardized. Each pharmacy sets its own cash price, and those prices can vary by hundreds of dollars for the same medication. Large chain pharmacies (CVS, Walgreens, Rite Aid) typically charge significantly more than independent pharmacies for generic medications.
The situation is worse for the 7.5% of Colorado residents without health insurance. Without an insurance negotiated rate, patients pay the pharmacy's full cash price — which can be astronomical compared to what insured patients pay.
Script Unlock changes this by creating real competition among Colorado pharmacies. Instead of accepting one pharmacy's price, you see verified prices from multiple pharmacies competing for your prescription. Most patients save 50-80% vs what they'd pay at a chain pharmacy.
Top 10 Most Prescribed Drugs in Colorado — Price Comparison
Estimated cash prices · Colorado · 2026
| Medication | Condition | Chain Price | Script Unlock Low |
|---|---|---|---|
| Metformin | Type 2 Diabetes | $54 | $13 |
| Lisinopril | High Blood Pressure | $46 | $11 |
| Atorvastatin | High Cholesterol | $50 | $11 |
| Amlodipine | High Blood Pressure | $42 | $11 |
| Omeprazole | GERD/Acid Reflux | $34 | $10 |
| Semaglutide | Type 2 Diabetes / Weight Loss | $1440 | $420 |
| Levothyroxine | Hypothyroidism | $26 | $9 |
| Gabapentin | Nerve Pain / Seizures | $38 | $10 |
| Losartan | High Blood Pressure | $48 | $11 |
| Albuterol | Asthma / COPD | $78 | $29 |
How to Save on Prescriptions in Colorado
Use Script Unlock to see verified prices from pharmacies near you in Colorado before driving anywhere.
Generic medications contain the same active ingredient as brand-name drugs and are held to the same FDA standards — at a fraction of the price.
Independent pharmacies in Colorado consistently outprice chains on generics. Script Unlock surfaces their prices so you can compare instantly.
Most pharmacies offer lower per-pill prices for 90-day supplies vs 30-day. Script Unlock can filter for pharmacies that offer this.
Some manufacturers offer free or reduced-price medications for qualifying patients. Script Unlock's prices are often competitive without the paperwork.
Frequently Asked Questions
How much do prescriptions cost in Colorado without insurance?
Prescription costs in Colorado vary widely. The same medication can cost 10× more at one pharmacy vs another. Script Unlock lets pharmacies compete for your prescription — most patients save 50-80% vs retail chain prices.
What is the cheapest pharmacy in Colorado?
The cheapest pharmacy varies by medication and location. Independent pharmacies in Colorado consistently offer lower prices than chains like CVS or Walgreens for generic medications. Script Unlock shows you verified prices from all nearby pharmacies.
Does Colorado have a prescription discount program?
Colorado may have state-sponsored discount programs for certain populations. Script Unlock's real-time pharmacy competition often provides deeper discounts without eligibility restrictions.
Compare Prescription Prices by State
Find the Lowest Prescription Prices in Colorado
Pharmacies in Colorado compete on Script Unlock. See verified prices instantly — free, no account required.
Compare Colorado Pharmacy Prices