CVS Pharmacy · Price Comparison 2026
Diphenhydramine at CVS Pharmacy: ~$15
CVS uses PBM-negotiated pricing. Cash prices vary but are often 40–60% above independent pharmacy rates. When independent pharmacies compete on Script Unlock, the same Diphenhydramine (Diphenhydramine Hydrochloride) is available from $2 — saving you $13 per fill.
CVS Pharmacy Price
~$15
typical cash price
Competing Pharmacies
From $2
when pharmacies compete
You Could Save
$13
vs CVS Pharmacy
Free · No account needed · Takes 30 seconds
Don't Pay CVS Pharmacy's $15 for Diphenhydramine
Pharmacies compete. You save $13. Takes 30 seconds.