Frontline Plus vs fipronil/methoprene for Dogs and cats
Frontline Plus is the brand name for fipronil/methoprene, prescribed for flea and tick prevention in dogs and cats. Generic fipronil/methoprene typically costs ~$19 at Script Unlock pharmacies vs $48 for brand at the vet — savings of ~$29 per fill.
Brand vs Generic — real pricing
Typical monthly pricing for a 30-day supply.
Prices are averages from recent Script Unlock pharmacy bids. Actual bid ranges vary by pharmacy, location, and quantity. Upload your vet's Rx to see live bids for your ZIP.
Are generics safe for dogs and cats?
Yes. FDA-approved generic pet medications must demonstrate bioequivalence to the brand — meaning the same active ingredient reaches the same blood concentration in the same time frame. Clinical effect is expected to be identical.
The only differences between brand Frontline Plus and generic fipronil/methoprene are:
- Manufacturer — different companies produce brand vs generic
- Packaging + inactive ingredients — different fillers, dyes, coatings (all FDA-approved)
- Price — typically 30-60% lower for the generic
A very small percentage of individual pets respond differently to generic vs brand — usually because of inactive ingredient sensitivity, not the active drug. If you notice any change in your dogs and cat's response after switching, consult your vet.
How to get generic fipronil/methoprene for your dogs and cat
Ask your vet at the next visit
Say: "Please write my dogs and cat's Frontline Plus prescription so it allows generic substitution." Most vets do this by default; a small number specifically write brand-only for clinical reasons.
Upload the Rx to Script Unlock
Photo or PDF at /upload-prescription. Note in the details field: "Generic acceptable" — pharmacies will bid on the generic if the Rx allows substitution.
Compare bids in 1-4 hours
Verified pharmacies submit competitive cash prices. Some bid brand, some bid generic — you see both and choose. Winning bids typically save 45-65% vs vet office.
Monitor closely on the first switch
Watch for any change in response for 2 weeks after switching from brand to generic. Rare individual pets are sensitive to inactive ingredients — contact your vet immediately if you notice anything unusual.
Frequently asked questions
Is fipronil/methoprene the same as Frontline Plus?↓
fipronil/methoprene is the FDA-approved generic version of Frontline Plus. Same active ingredient, same clinical effect, same dosing. The difference is manufacturer, packaging, and price. Generic versions of pet medications are FDA-regulated to be bioequivalent to the brand.
How much cheaper is generic fipronil/methoprene vs brand Frontline Plus?↓
Generic fipronil/methoprene typically costs ~$19 at Script Unlock pharmacies vs $35 for brand Frontline Plus — savings around $16 per fill (~45%). For chronic prescriptions that's hundreds of dollars per year.
Will my vet write a prescription for generic fipronil/methoprene?↓
Yes — most vets will write a prescription that allows generic substitution. Ask specifically: "Please write this for generic fipronil/methoprene so I can compare pharmacy prices." Some vets specifically write brand-only prescriptions if there's a clinical reason.
Is generic fipronil/methoprene as effective as brand Frontline Plus for dogs and cats?↓
FDA-approved generics for pet medications must demonstrate bioequivalence — the active ingredient reaches the same concentration in the same time as brand. Clinical effect is expected to be identical. Rare individual pets may respond differently — discuss with your vet before switching.
Find the lowest your pet's frontline plus cash price
Upload your your pet's frontline plus prescription and verified pharmacies bid for your fill. 100% free for patients. No insurance, no membership, no sign-up.
Free for patients. No insurance, no membership, no sign-up required.