How Much Does Frontline Plus Cost for Dogs and cats in 2026?
Frontline Plus for dogs and cats typically costs ~$48 at vet offices (30-day supply) and ~$35 through verified Script Unlock pharmacies — a savings of $13 (27%) per fill. For chronic prescriptions, that's ~$156/year in your pocket.
Frontline Plus price breakdown
Typical 30-day supply pricing (chronic medications). Actual bid ranges vary by ZIP + pharmacy.
What drives Frontline Plus pricing?
Same medication, wildly different prices — here's why.
Distribution channel
Vet offices carry retail markup — often 40-60% above pharmacy dispensing cost. Same manufacturer, same medication, but a fundamentally different distribution model.
Pharmacy competition
In a vacuum, a pharmacy sets one price. When pharmacies bid against each other for the same prescription, they price against competitors — that's the Script Unlock lever.
Volume + geography
Pharmacies in dense metros with high topical antiparasitic (spot-on) volume have lower cost bases + bid more aggressively. Rural pharmacies often bid competitively to win volume they can't get locally.
Brand vs generic
Generic fipronil/methoprene is often 40-60% cheaper than brand Frontline Plus. Ask your vet if generic substitution is clinically appropriate.
Quantity dispensed
90-day supplies typically cost 15-30% less per unit than 30-day. Ask your vet if a 90-day prescription is clinically appropriate for your dogs and cat's condition.
Time of month + season
Pharmacies with excess inventory bid more aggressively. Manufacturer rebate cycles + seasonal demand shifts (flea/tick season, allergy season) affect competitive intent.
Frequently asked questions about Frontline Plus pricing
How much does Frontline Plus cost for dogs and cats in 2026?↓
Frontline Plus for dogs and cats typically costs ~$48 at vet offices (30-day supply) and ~$35 through verified Script Unlock pharmacies. That's a savings of $13 per fill (27%). For chronic prescriptions filled monthly, that's ~$156/year.
Why is Frontline Plus cheaper at Script Unlock than at the vet?↓
Vet offices carry high overhead — clinical staff, exam room space, retail markup. When pharmacies compete for your prescription, they price against each other, not against your relationship with the vet. Same topical antiparasitic (spot-on), same manufacturer, different distribution channel.
Do I need pet insurance to save on Frontline Plus?↓
No. Script Unlock is a cash-pay marketplace. Verified pharmacies bid competitive cash prices — often less than what pet insurance would cover after your deductible. For routine chronic prescriptions like Frontline Plus, cash-pay through Script Unlock typically beats insurance.
Are Frontline Plus prices the same across every pharmacy?↓
No — this is exactly why Script Unlock exists. The same Frontline Plus prescription can vary $14-$53 between pharmacies. Location, volume, contracts, competitive intent — all drive pricing. Bidding surfaces the low price for your ZIP.
Does the cost of Frontline Plus include shipping?↓
Winning bids on Script Unlock include shipping cost upfront (or specify pickup). You see the total price you'll pay before you commit. No surprise fees at checkout, no hidden shipping markups.
Can I save more on Frontline Plus by buying larger quantities?↓
Often yes. Ask your vet to write a 90-day prescription instead of 30-day for chronic medications. Many pharmacies offer bulk discounts. Script Unlock pharmacies typically bid 5-15% additional discount on 90-day quantities. Ask your vet if a 90-day supply is clinically appropriate for your dogs and cat.
Find the lowest your pet's frontline plus cash price
Upload your your pet's frontline plus prescription and verified pharmacies bid for your fill. 100% free for patients. No insurance, no membership, no sign-up.
Free for patients. No insurance, no membership, no sign-up required.