Kisspeptin
Kisspeptin-10 / Kisspeptin-54
Kisspeptin is a naturally occurring neuropeptide that plays a master regulatory role in the hypothalamic-pituitary-gonadal (HPG) axis. It controls the release of GnRH, which drives testosterone and estrogen production.
Pricing Overview
Brand / Retail Price
N/A
Compounded / Cash Pay
$80–$250/month
Compare pricing at compounding pharmacies — significant variation exists
Primary Uses
How Kisspeptin Works
Kisspeptin binds to the KISS1R receptor on GnRH neurons in the hypothalamus, triggering gonadotropin-releasing hormone (GnRH) pulses that stimulate LH and FSH release, which drive testosterone and fertility.
Dosing Information
Typical Dose
100–500mcg daily
Frequency
1–2 times daily
Administration
Subcutaneous injection
Notes
Used in fertility clinics as alternative to hCG; works through natural HPG axis
Side Effects & Safety
Common
- • Injection site irritation
- • Mild headache
- • Flushing
Serious
- • Hormonal fluctuations during initial use
- • Limited long-term safety data
Rare
- • Mood changes
- • Fatigue
Frequently Asked Questions
Can kisspeptin replace TRT?
Kisspeptin stimulates your body to produce its own testosterone naturally, preserving fertility (unlike exogenous TRT which suppresses sperm production). It may work for mild-moderate low T but is less effective than TRT for severe deficiency.
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