PT-141 (Bremelanotide)
Bremelanotide
PT-141 (Bremelanotide, brand name Vyleesi) is an FDA-approved melanocortin receptor agonist for hypoactive sexual desire disorder (HSDD) in premenopausal women. Also used off-label for male sexual dysfunction.
Pricing Overview
Brand / Retail Price
$800–$1,000/month (Vyleesi)
Compounded / Cash Pay
$50–$200/month
Compounded PT-141 saves 80%+ vs brand-name Vyleesi
Primary Uses
How PT-141 (Bremelanotide) Works
PT-141 activates melanocortin-4 receptors (MC4R) in the central nervous system, directly stimulating sexual desire pathways in the brain — unlike PDE5 inhibitors (Viagra/Cialis) which work on blood flow.
Dosing Information
Typical Dose
1.75mg per dose
Frequency
As needed, minimum 24 hours between doses
Administration
Subcutaneous injection
Notes
Max 8 doses per month; take 45 minutes before anticipated activity
Side Effects & Safety
Common
- • Nausea (40% of users)
- • Flushing
- • Headache
- • Injection site reactions
Serious
- • Blood pressure changes
- • Skin hyperpigmentation (with repeated use)
Rare
- • Severe nausea/vomiting
Frequently Asked Questions
How is PT-141 different from Viagra?
PT-141 works in the brain to increase sexual desire, while Viagra/Cialis work on blood vessels to improve blood flow. PT-141 addresses "want to" while PDE5 inhibitors address "able to." PT-141 also works for women, unlike Viagra.
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