Trimethoprim/Sulfamethoxazole Side Effects
Common and serious side effects of Trimethoprim/Sulfamethoxazole (Trimethoprim / Sulfamethoxazole) — what to expect and how to manage them.
Common Side Effects
- Diarrhea or loose stools
- Nausea
- Stomach cramps
- Loss of appetite
- Yeast infections (vaginal or oral)
- Skin rash
Serious Side Effects
Seek immediate care if severe- Clostridioides difficile (C. diff) infection
- Severe allergic reaction / anaphylaxis
- Tendon rupture (fluoroquinolones)
- QT prolongation (some antibiotics)
- Stevens-Johnson syndrome (rare)
Managing Side Effects
- Take the full course — never stop early even if feeling better
- Probiotics during and after may reduce diarrhea
- Report rash or breathing difficulty immediately
- Take with food unless instructed otherwise
- Avoid dairy with some antibiotics (check with pharmacist)
What Your Doctor May Monitor
Signs of allergic reactionDiarrhea severityKidney function (some antibiotics)
Trimethoprim/Sulfamethoxazole Cash Price
Trimethoprim/Sulfamethoxazole cash prices start from $9 when pharmacies compete on Script Unlock — up to 55% below retail. No insurance required.
Compare Trimethoprim/Sulfamethoxazole PricesMedical Disclaimer: This information is for educational reference only. Side effects vary by individual, dose, and other medications. Always consult your healthcare provider for personalized medical advice. Do not stop or change your medication without medical guidance.