How Much Is Sulfamethoxazole/Trimethoprim Without Insurance?
How much is Sulfamethoxazole/Trimethoprim without insurance?
Without insurance, Sulfamethoxazole/Trimethoprim typically costs from $3/month when you compare pharmacies through Script Unlock. Cash-pay prices are set by pharmacies competing directly for your prescription — no PBM, no discount card required. Most patients save 82% vs the retail sticker price at chain pharmacies.
- Chain pharmacy retail price: $18–$24/month
- Script Unlock cash price: from $3/month (82% off)
- Annual savings: up to $180/year vs retail
Sulfamethoxazole/Trimethoprim (Sulfamethoxazole/Trimethoprim) costs from $3/month without insurance when pharmacies compete on Script Unlock — versus $18–$24 at retail chain pharmacies. That's up to $180/year saved.
Updated July 2026 · Verified pharmacy data
Sulfamethoxazole/Trimethoprim Cash Price Comparison — 2026
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Why is Sulfamethoxazole/Trimethoprim so expensive without insurance?
Chain pharmacies (CVS, Walgreens, Rite Aid, Walmart) set high cash prices for Sulfamethoxazole/Trimethoprimbecause their pricing engines are optimized for insurance-paid customers, not cash-pay patients. Cash pay at a chain often runs 3–5× the true wholesale price.
Independent pharmacies on Script Unlock — the ones bidding for your prescription — compete for your business. They don't need to protect insurance contracts. Their cash price reflects what Sulfamethoxazole/Trimethoprim actually costs plus a fair margin. That's why Sulfamethoxazole/Trimethoprim on Script Unlock lands at $3/month instead of $18+.