How Much Is Esketamine Without Insurance?
How much is Esketamine without insurance?
Without insurance, Esketamine typically costs from $723/month when you compare pharmacies through Script Unlock. Cash-pay prices are set by pharmacies competing directly for your prescription — no PBM, no discount card required. Most patients save 15% vs the retail sticker price at chain pharmacies.
- Chain pharmacy retail price: $850–$1148/month
- Script Unlock cash price: from $723/month (15% off)
- Annual savings: up to $1524/year vs retail
Esketamine (Esketamine Hydrochloride) costs from $723/month without insurance when pharmacies compete on Script Unlock — versus $850–$1148 at retail chain pharmacies. That's up to $1524/year saved.
Updated July 2026 · Verified pharmacy data
Esketamine Cash Price Comparison — 2026
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Why is Esketamine so expensive without insurance?
Chain pharmacies (CVS, Walgreens, Rite Aid, Walmart) set high cash prices for Esketaminebecause their pricing engines are optimized for insurance-paid customers, not cash-pay patients. Cash pay at a chain often runs 3–5× the true wholesale price.
Independent pharmacies on Script Unlock — the ones bidding for your prescription — compete for your business. They don't need to protect insurance contracts. Their cash price reflects what Esketamine actually costs plus a fair margin. That's why Esketamine on Script Unlock lands at $723/month instead of $850+.