How Long Does Fluoxetine Stay in Your System?
Half-life
1-6 days (active metabolite: 4-16 days)
Typical detection
1-4 weeks in urine
Key Facts About Fluoxetine Clearance
- Longest half-life of all SSRIs
- Active metabolite norfluoxetine extends effects
- Safest SSRI to stop — discontinuation syndrome less severe
How long does Fluoxetine stay in your system?
Fluoxetine (Fluoxetine Hydrochloride) has a half-life of 1-6 days (active metabolite: 4-16 days). This means it takes approximately 1-6 days (active metabolite: 4-16 days) for the drug concentration in your blood to be reduced by half. Typical urine detection window: 1-4 weeks in urine. Individual factors like kidney function, age, and genetics can significantly affect these timeframes.
How long does Fluoxetine take to work?
The onset of Fluoxetine action varies by condition. Some effects are immediate; others (like antidepressants) take 2-6 weeks for full benefit. Ask your prescriber when to expect results.
This information is for educational purposes only. Individual clearance times vary. Consult your healthcare provider for medical advice.