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    Home/Medications/Levothyroxine

    Thyroid Hormones

    LevothyroxineLevothyroxine Sodium

    Levothyroxine is synthetic thyroid hormone taken once a day, on an empty stomach, to treat an underactive thyroid. It is sold as Synthroid, Levoxyl, Unithroid, Euthyrox, Tirosint and as generics, and switching between makers is discouraged without a follow-up blood test.

    Written by the Script Unlock editorial teamLast updated September 27, 2026Not yet reviewed by an independent pharmacist

    This page is general information about a medication and how cash prices for it are set. It is not medical advice and does not replace the label, your prescriber or your pharmacist. How we handle medical information

    Brand names
    Synthroid, Levoxyl, Tirosint, Unithroid, Euthyrox
    Generic available in the US
    Yes
    Dosage forms
    Tablet; Liquid-filled capsule (Tirosint); Oral solution (Tirosint-SOL, Thyquidity, Ermeza)
    Strengths on US labels
    25, 50, 75, 88, 100, 112, 125, 137, 150, 175, 200 and 300 mcg tablets
    Commonly prescribed for
    Hypothyroidism, Thyroid Cancer, Goiter, Hashimoto's Disease

    Tablets are generic from several manufacturers, and several brands are themselves inexpensive. Capsules and solutions are brand products.

    About Levothyroxine

    Levothyroxine replaces the hormone the thyroid gland is not making enough of. It is one of the most prescribed drugs in the country and is usually taken for life. Because the body is sensitive to small changes in thyroid hormone, it is dosed in micrograms across a dozen tablet strengths, and the dose is adjusted against a blood test rather than symptoms alone.

    Absorption is easily disturbed. It is taken on an empty stomach, usually first thing in the morning, well apart from food, coffee, calcium, iron, antacids and some other medicines. The FDA considers levothyroxine a narrow therapeutic index drug: different manufacturers’ tablets are approved as bioequivalent, but the tolerances are tight enough that many endocrinologists prefer a patient stay on one maker, and ask for a blood test a few weeks after any switch.

    Tirosint is a liquid-filled capsule and Tirosint-SOL a solution; both avoid the fillers in tablets and are used for people with absorption problems or excipient sensitivities. They are priced as brand products.

    Why the cash price for Levothyroxine differs from pharmacy to pharmacy

    Generic levothyroxine tablets are cheap for pharmacies to buy, so the cash price is mostly fee and mark-up. The complication is manufacturer consistency: if you and your prescriber want to stay on one maker, you are limited to pharmacies that stock it, and a pharmacy that has to special-order a specific manufacturer may charge more.

    Brand pricing is unusual for this drug. Some brands are priced only modestly above generics and a few pharmacies price a brand below their own generic; the capsule and liquid forms are the ones that cost substantially more.

    Ways to pay less for Levothyroxine without insurance

    • Ask your prescriber and pharmacist to keep you on one manufacturer, and ask the pharmacy to note it on your profile so refills do not switch silently.
    • Ask for a ninety-day prescription; a single dispensing fee a quarter matters on a lifelong generic.
    • Ask the pharmacy to quote both the generic and the brand you have used; the gap is sometimes smaller than expected.
    • If a capsule or liquid form has been prescribed, ask whether a tablet taken correctly would give the same result for you; only change if the prescriber agrees.
    • Upload your prescription to Script Unlock so licensed pharmacies can quote their cash price for the strength and manufacturer you need. You pay the pharmacy directly.

    How Script Unlock gets you a cash price for Levothyroxine

    Prices on this site come from pharmacies responding to a real prescription. We do not publish estimated, average or "typical" prices, because none of those would be your price.

    1. 1You upload your prescription

      A photo of your Levothyroxine prescription is enough. Nothing is sold on the site; you are asking pharmacies to quote.

    2. 2Licensed pharmacies respond

      Pharmacies that Script Unlock has verified see the request and each can reply with its own cash price for your exact drug, strength and quantity.

    3. 3You choose and pay the pharmacy

      You compare the responses, pick a pharmacy, and pay that pharmacy directly when you collect. Script Unlock never takes a patient payment and never sets the price.

    Upload a Levothyroxine prescriptionWhat Script Unlock cannot do

    Questions to ask your pharmacist about Levothyroxine

    1. 1.Is this the same manufacturer as my last fill?
    2. 2.How long should I wait after taking it before coffee, food or other medicines?
    3. 3.Which supplements interfere with absorption?
    4. 4.What should I do if I miss a dose?
    5. 5.When should my thyroid blood test be repeated after a change?

    Related medications

    MetforminAtorvastatinOmeprazoleLiothyronineLevothyroxine (Gel Cap)

    Sources

    • FDA-approved labeling on DailyMed (levothyroxine)
    • FDA Orange Book (approved generics and therapeutic equivalence)
    • MedlinePlus drug information (National Library of Medicine)

    Script Unlock is a marketplace that lets licensed pharmacies quote a cash price on your prescription. It does not prescribe, dispense or sell medication, does not process patient payments, and does not give medical advice. Always follow the instructions of your prescriber and pharmacist and read the medication guide supplied with your medicine.

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    You pay the pharmacy directly
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    Upload your prescription and licensed, verified pharmacies each quote their own cash price. You pay the pharmacy directly.

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