Why Is Setmelanotide So Expensive?(And How to Pay $3825 Instead)
Setmelanotide averages $4500/month at US retail. Through Script Unlock pharmacy bidding, the same prescription typically costs $3825/month. Here's exactly why retail is so high — and how to stop paying it.
5 Real Reasons Setmelanotide Costs So Much
Limited Generic Manufacturers
Generic Setmelanotide is technically off-patent, but only a handful of manufacturers produce it in the US. Concentrated supply lets manufacturers and chains keep prices elevated. The active ingredient costs cents to produce — the price you see reflects market concentration, not manufacturing cost.
PBM Spread Pricing
Pharmacy benefit managers (PBMs) sit between insurance plans and pharmacies. PBMs charge plans a higher price and pay pharmacies less — pocketing the spread. For high-volume drugs like Setmelanotide, this spread can be substantial. You see it as your copay; the PBM books it as profit.
Manufacturer Pricing Power
Setmelanotide's manufacturer sets the wholesale acquisition cost (WAC) — the "list price" — independent of production costs. US drug prices are not regulated at the federal level. WAC for Setmelanotide has risen above the general inflation rate for the past decade, driving up both copays and uninsured cash prices.
Insurance Tier System
Insurance formularies place Setmelanotide on a tier. Higher tiers mean higher copays — and tier placement depends partly on rebate deals between PBMs and the manufacturer, not on clinical evidence. If your plan assigns Setmelanotide to tier 3 or higher, you absorb the cost of that negotiation.
Pharmacy Margin Variance
Pharmacies set their own cash prices for Setmelanotide. National chains target 30–40% margins using insurance reimbursement formulas even for cash patients. Independents often accept lower margins to win volume. Same Setmelanotide script — $3825 at one pharmacy, $4500 at another, two miles apart.
The Middlemen Taking a Cut of Setmelanotide
Between the factory and your medicine cabinet, 5 parties each take a margin on every $4500 you pay.
Script Unlock removes the PBM from the chain and lets pharmacies compete directly — collapsing the markup stack.
Setmelanotide Price Has Risen ~186% Since 2016
Estimated average US retail price trend for Setmelanotide over the past decade.
Historical estimates based on CMS NADAC data and PBM rate trends. Actual price growth varies by Setmelanotide dose and formulation.
What You Can Do Right Now
5 actions that take under 10 minutes — most patients achieve the full 15% saving off Setmelanotide retail.
- 1Compare cash prices via Script Unlock pharmacy bidding — Setmelanotide bids average $3825/month (15% below the $4500 retail).
- 2Ask your pharmacist to try a different Setmelanotide manufacturer. The same generic molecule from different makers can vary 30–50% in pharmacy acquisition cost.
- 3Request a 90-day supply of Setmelanotide instead of monthly. Typical saving: 10–15% per fill.
- 4Check Setmelanotide manufacturer patient assistance. If your income qualifies, the medication may be free or deeply discounted.
- 5Compare your insurance copay to the cash price every refill. For Setmelanotide, many patients pay less cash than their copay — especially before hitting the deductible.
“I was paying $4500/month until I found pharmacy bidding”
“I’d been filling Setmelanotide at the same chain for two years — $4500 every month without question. I assumed that was just what it cost. My insurance covered some of it, but not enough. Then I uploaded the prescription to Script Unlock. Within five minutes I had four bids: $3825, $$3829, $$3834, and $$3150. The cheapest was an independent pharmacy I’d driven past a hundred times. I switched. I’m saving $675/month — $8100/year. Same medication. Same dose. Same generic. The only thing different is someone competing for my prescription instead of assuming I’d just keep paying.”
— Representative patient experience based on Script Unlock Setmelanotide bid data. Individual savings vary by zip code, dose, and quantity.
Pharmacies bid to win your Setmelanotide prescription. Prices go lower than any pre-set coupon or discount card — because they’re competing against the pharmacy down the street.
Frequently Asked Questions — Why Setmelanotide Costs So Much
Why is Setmelanotide so expensive in the US?
Setmelanotide is expensive primarily due to concentrated generic manufacturing, PBM spread pricing, and chain pharmacies anchoring cash prices to insurance formulas. The US is the only high-income country without regulated or nationally negotiated drug pricing. The same Setmelanotide costs 60–80% less in Canada, the UK, or Australia.
How much should Setmelanotide actually cost?
Script Unlock pharmacy bidding regularly produces Setmelanotide fills at $3825/month — close to the floor price most pharmacies can sustainably offer. That's 15% below the standard retail of $4500. The manufacturing cost of most small-molecule drugs is a tiny fraction of even this discounted price.
Why has the price of Setmelanotide gone up?
Setmelanotide retail prices have increased approximately 186% over the past decade — from around $1575 to $4500/month. Drivers include manufacturer list-price hikes, PBM rebate inflation, pharmacy chain consolidation, and the absence of a US price ceiling.
What is the cheapest way to get Setmelanotide?
Cheapest path today: (1) Script Unlock pharmacy bids — avg $3825/month. (2) Different Setmelanotide manufacturer — sometimes 30–50% cheaper for the same generic. (3) 90-day supply — saves ~15% per fill. (4) Manufacturer patient assistance if you qualify. (5) Compare cash to insurance copay — cash is often lower.
Is Setmelanotide cheaper without insurance?
For many patients, yes. Setmelanotide cash via Script Unlock ($3825/month) often costs less than the insurance copay — especially on tier 2/3 formulary plans. Compare every fill before paying via insurance.
Does Medicare cover Setmelanotide?
Coverage depends on your specific Part D plan. Setmelanotide is usually covered but tier placement and prior auth vary. In the donut hole (coverage gap), paying cash via Script Unlock ($3825/month) is often cheaper than the gap-phase copay. This is legal and allowed — no need to use insurance if the cash price is lower.
Compare Setmelanotide prices now — pharmacies compete
Stop overpaying. Free. 60 seconds. No insurance card. Pharmacies bid on your Setmelanotide prescription.
Stop Overpaying for SetmelanotideAverage saving: $675/month · $8100/year