Semaglutide Price Comparison 2026 — Ozempic vs Wegovy vs Compounded
Brand-name semaglutide can run more than $1,300/month. Compounded semaglutide from a licensed pharmacy can be 75–85% cheaper. Here's every form side-by-side, what each is approved for, and where Script Unlock can find it near you.
| Drug | Form | Dose / week | Approved for | Price / month | On Script Unlock |
|---|---|---|---|---|---|
| Ozempic | Subcutaneous injection | 0.5–2 mg/week | Type 2 diabetes (off-label weight loss) | $968/month | Yes |
| Wegovy | Subcutaneous injection | 2.4 mg/week | Chronic weight management | $1,349/month | Yes |
| Rybelsus | Oral tablet | 3–14 mg/day | Type 2 diabetes only | $800/month | Yes |
| Compounded semaglutide | Subcutaneous injection (custom) | Custom (typically 0.25–2 mg/week) | Off-label — prescriber discretion | $150–400/month | Yes |
Prices reflect typical 2026 cash list prices in the United States before manufacturer coupons or insurance. Compounded pricing varies by pharmacy, dose, and formulation. Brand-name list prices sourced from public 2026 wholesale data.
Why does semaglutide price vary so much?
Medical disclaimer
This page is for general information only and is not medical advice. Semaglutide is a prescription medication with serious potential side effects, including pancreatitis, gallbladder disease, and thyroid C-cell tumours in animal studies. Do not start, stop, or switch between branded and compounded semaglutide without speaking to a qualified prescriber. Script Unlock does not prescribe medication.
Frequently Asked Questions
What is the cheapest form of semaglutide?
Compounded semaglutide from a licensed compounding pharmacy is typically the cheapest form, ranging from $150–400/month depending on dose. Brand-name Ozempic is around $968/month, Wegovy is $1,349/month, and oral Rybelsus is around $800/month before insurance or coupons.
Is compounded semaglutide safe?
Compounded semaglutide from a licensed, accredited 503A or 503B compounding pharmacy is generally considered safe when prescribed and monitored by a physician. Always verify the pharmacy holds a valid state license, ideally PCAB accreditation, and provides a Certificate of Analysis. Avoid unregulated online sources, peptide vendors, and "research-only" suppliers — those are not pharmacies.
Which insurance covers semaglutide?
Most commercial insurance plans cover Ozempic and Rybelsus when prescribed for type 2 diabetes (with prior authorisation). Wegovy coverage for weight loss is much more limited and varies by employer plan. Medicare Part D currently does not cover GLP-1 drugs prescribed solely for weight loss. Compounded semaglutide is rarely covered by insurance, but is often cheaper out-of-pocket than the brand-name copay.
Can I get semaglutide without a prescription?
No. All forms of semaglutide — brand-name and compounded — require a valid prescription from a licensed prescriber. Any website offering semaglutide without a prescription is operating illegally and the product cannot be verified. A legitimate telehealth visit followed by a prescription sent to a licensed pharmacy is the only safe route.
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