How Much Does Comfortis Cost for Dogs and cats in 2026?
Comfortis for dogs and cats typically costs ~$55 at vet offices (30-day supply) and ~$38 through verified Script Unlock pharmacies — a savings of $17 (31%) per fill. For chronic prescriptions, that's ~$204/year in your pocket.
Comfortis price breakdown
Typical 30-day supply pricing (chronic medications). Actual bid ranges vary by ZIP + pharmacy.
What drives Comfortis pricing?
Same medication, wildly different prices — here's why.
Distribution channel
Vet offices carry retail markup — often 40-60% above pharmacy dispensing cost. Same manufacturer, same medication, but a fundamentally different distribution model.
Pharmacy competition
In a vacuum, a pharmacy sets one price. When pharmacies bid against each other for the same prescription, they price against competitors — that's the Script Unlock lever.
Volume + geography
Pharmacies in dense metros with high oral flea adulticide volume have lower cost bases + bid more aggressively. Rural pharmacies often bid competitively to win volume they can't get locally.
Brand vs generic
Generic spinosad is often 40-60% cheaper than brand Comfortis. Ask your vet if generic substitution is clinically appropriate.
Quantity dispensed
90-day supplies typically cost 15-30% less per unit than 30-day. Ask your vet if a 90-day prescription is clinically appropriate for your dogs and cat's condition.
Time of month + season
Pharmacies with excess inventory bid more aggressively. Manufacturer rebate cycles + seasonal demand shifts (flea/tick season, allergy season) affect competitive intent.
Frequently asked questions about Comfortis pricing
How much does Comfortis cost for dogs and cats in 2026?↓
Comfortis for dogs and cats typically costs ~$55 at vet offices (30-day supply) and ~$38 through verified Script Unlock pharmacies. That's a savings of $17 per fill (31%). For chronic prescriptions filled monthly, that's ~$204/year.
Why is Comfortis cheaper at Script Unlock than at the vet?↓
Vet offices carry high overhead — clinical staff, exam room space, retail markup. When pharmacies compete for your prescription, they price against each other, not against your relationship with the vet. Same oral flea adulticide, same manufacturer, different distribution channel.
Do I need pet insurance to save on Comfortis?↓
No. Script Unlock is a cash-pay marketplace. Verified pharmacies bid competitive cash prices — often less than what pet insurance would cover after your deductible. For routine chronic prescriptions like Comfortis, cash-pay through Script Unlock typically beats insurance.
Are Comfortis prices the same across every pharmacy?↓
No — this is exactly why Script Unlock exists. The same Comfortis prescription can vary $15-$57 between pharmacies. Location, volume, contracts, competitive intent — all drive pricing. Bidding surfaces the low price for your ZIP.
Does the cost of Comfortis include shipping?↓
Winning bids on Script Unlock include shipping cost upfront (or specify pickup). You see the total price you'll pay before you commit. No surprise fees at checkout, no hidden shipping markups.
Can I save more on Comfortis by buying larger quantities?↓
Often yes. Ask your vet to write a 90-day prescription instead of 30-day for chronic medications. Many pharmacies offer bulk discounts. Script Unlock pharmacies typically bid 5-15% additional discount on 90-day quantities. Ask your vet if a 90-day supply is clinically appropriate for your dogs and cat.
Find the lowest your pet's comfortis cash price
Upload your your pet's comfortis prescription and verified pharmacies bid for your fill. 100% free for patients. No insurance, no membership, no sign-up.
Free for patients. No insurance, no membership, no sign-up required.