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    Home/Pet Prescriptions/Heartgard Plus/For Heartworm Prevention
    Heartworm preventive / anthelmintic · For Heartworm Prevention

    Heartgard Plus for Heartworm Prevention in Dogs

    ScriptUnlock editorial·Last reviewed July 5, 2026·Cash-price data refreshed in real time at fill

    Heartgard Plus (ivermectin/pyrantel) is a heartworm preventive / anthelmintic used to treat heartworm disease prevention in dogs. Vet offices typically charge $65; Script Unlock pharmacies fill it for ~$48 — saving you $17 (26%) per fill.

    Upload Your Vet Rx Back to Heartgard Plus main page
    Manually verifiedAll pharmacies and compounding vets on Script Unlock are manually verified by our team before they can bid on your pet’s prescription.See our pharmacy verification process
    Vet Office
    $65
    Script Unlock
    $48
    You Save
    $17/mo

    How Heartgard Plus is used for heartworm prevention

    Heartgard Plus belongs to the Heartworm preventive / anthelmintic class of medications. Veterinarians commonly prescribe it for heartworm disease prevention in dogs because of its established safety profile and clinical effectiveness for this indication.

    Species considerations: Heartgard Plus is approved for use in dogs. Dosing, frequency, and monitoring vary by species — your vet determines the exact protocol for your pet.

    Prescription requirement: Heartgard Plus requires a written prescription from a licensed US veterinarian with a valid vet-client-patient relationship. Script Unlock only fills valid vet-written prescriptions; we don't sell medications directly.

    Chronic condition math

    Because Heartworm Prevention in pets is often a chronic condition, monthly savings on Heartgard Plus compound quickly. At $17/month × 12 months = $204/year back in your pocket for the same medication.

    Other medications for heartworm prevention

    Your vet may consider these as alternatives or add-ons to Heartgard Plus for heartworm disease prevention in dogs.

    Revolution
    selamectin
    26%
    $65$48

    Topical antiparasitic

    Simparica
    sarolaner
    24%
    $62$47

    Isoxazoline antiparasitic

    Always work with your vet

    This page is educational only. Heartgard Plus for heartworm prevention must be prescribed by a licensed US veterinarian who has examined your pet. Never medicate your pet without a valid prescription. Script Unlock is a prescription marketplace, not a veterinary practice.

    Frequently asked questions

    Is Heartgard Plus used for heartworm prevention in dogs?↓

    Yes — Heartgard Plus is commonly prescribed by veterinarians for heartworm disease prevention in dogs. It's a heartworm preventive / anthelmintic. Your vet determines whether it's clinically appropriate for your pet's specific situation, weight, and other medications.

    How much does Heartgard Plus for heartworm prevention cost?↓

    Vet offices typically charge ~$65 per fill; verified Script Unlock pharmacies bid at ~$48. That's a savings of $17 (26%) per fill. For chronic heartworm prevention treatment, that's ~$204/year.

    What are alternatives to Heartgard Plus for heartworm prevention?↓

    Other medications commonly used for heartworm disease prevention: Revolution, Simparica. Each has different indications, side-effect profiles, and pricing. Only your vet can determine which is clinically appropriate for your dog.

    Do I need a new prescription to get Heartgard Plus for heartworm prevention via Script Unlock?↓

    Yes — Script Unlock only fills valid vet-written prescriptions. Your vet writes the Rx after determining Heartgard Plus is right for your pet. You then upload the Rx to Script Unlock, and verified pharmacies bid.

    Can I fill my pet's Heartgard Plus prescription at a human pharmacy?↓

    Yes — most US-licensed retail and compounding pharmacies can fill veterinary prescriptions. Script Unlock connects you to verified pharmacies that compete on price for your pet's Rx.

    Related
    Heartgard Plus main pageHeartgard Plus CostGeneric vs BrandAll pet medicationsPet Owners Hub

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