Pituitary Pars Intermedia Dysfunction (PPID / Equine Cushing's) in Horses
PPID affects ~20% of horses over 15 years. Diagnosis: basal ACTH + seasonal context (autumn elevation). Pergolide is the FDA-approved treatment (Prascend).
Pergolide can cause anorexia (10-15% of horses) in first 2 weeks. Half-dose taper-up reduces incidence.
Symptoms to watch for
- •Hirsutism (long, curly, persistent winter coat)
- •Delayed seasonal shedding
- •Loss of topline muscle
- •Pot-bellied appearance
- •Laminitis (most serious complication)
- •Recurrent infections, slow wound healing
Treatment options
Prascend — dopamine agonist. FDA-approved. Compounded paste available at lower cost; ensure stability-validated source.
Valid vet prescription required · HIPAA-compliant · Free to pet owners
FAQs — Pituitary Pars Intermedia Dysfunction (PPID / Equine Cushing's) in Horses
Sources & review
Reviewed by: ScriptUnlock Pharmacy Verification Team
Last reviewed: June 2026
Sources cited:
- • Equine Endocrinology Group PPID Guidelines
- • Prascend FDA Label
This information is educational and does not substitute for veterinary advice. Always confirm diagnosis, dosing, and treatment plan with your veterinarian. ScriptUnlock connects pet owners to verified pharmacies; we do not provide veterinary advice.