Osteoarthritis in Dogs
Canine OA affects ~20% of all dogs and >80% of dogs over 8 years. Multi-modal management combines weight control, physiotherapy, NSAIDs, monoclonal antibody therapy (bedinvetmab), adjunct analgesics, and joint supplements.
NEVER use NSAIDs concurrently with corticosteroids — GI ulceration risk. 7-day washout required when switching.
Symptoms to watch for
- •Stiffness after rest, warming out of it
- •Reluctance to climb stairs or jump
- •Lameness or limping
- •Decreased exercise tolerance
- •Muscle atrophy in affected limb
- •Behavioral change (grumpy, withdrawn)
Treatment options
Librela — anti-NGF mAb. Monthly SC. Renal-safe alternative to NSAIDs.
Rimadyl — FDA-approved canine NSAID. Hepatic monitoring at 2 + 8 weeks.
Metacam — FDA-approved canine NSAID. Once-daily dosing.
Neuropathic pain adjunct. Compounded liquid for small breeds.
NMDA antagonist for refractory OA pain.
Grapiprant — EP4 antagonist. Safer GI profile than traditional NSAIDs.
Valid vet prescription required · HIPAA-compliant · Free to pet owners
FAQs — Osteoarthritis in Dogs
Sources & review
Reviewed by: ScriptUnlock Pharmacy Verification Team
Last reviewed: June 2026
Sources cited:
- • AAHA Pain Management Guidelines
- • WSAVA Pain Council
- • Bedinvetmab FDA Label
This information is educational and does not substitute for veterinary advice. Always confirm diagnosis, dosing, and treatment plan with your veterinarian. ScriptUnlock connects pet owners to verified pharmacies; we do not provide veterinary advice.