Hyperadrenocorticism (Cushing's Disease) in Dogs
Canine Cushing's is 85% pituitary-dependent (PDH), 15% adrenal-dependent. Diagnosis: LDDST + ACTH stim + abdominal US. Trilostane is first-line in both PDH and adrenal cases.
Iatrogenic hypoadrenocorticism (Addisonian crisis) is the major complication of trilostane. Pre + 10-14d + every-3-month ACTH stim monitoring required.
Symptoms to watch for
- •Polydipsia, polyuria (hallmark)
- •Polyphagia
- •Truncal alopecia, thin skin
- •Pot-bellied appearance
- •Panting
- •Recurrent UTIs
- •Skin calcinosis cutis (advanced)
Treatment options
Vetoryl — competitive 3β-HSD inhibitor. Compounded mini-capsules enable precise BID dosing.
Adrenocorticolytic. Older first-line; now mostly reserved for trilostane failures.
Valid vet prescription required · HIPAA-compliant · Free to pet owners
FAQs — Hyperadrenocorticism (Cushing's Disease) in Dogs
Sources & review
Reviewed by: ScriptUnlock Pharmacy Verification Team
Last reviewed: June 2026
Sources cited:
- • ACVIM Consensus on Hyperadrenocorticism
- • Trilostane FDA Label
This information is educational and does not substitute for veterinary advice. Always confirm diagnosis, dosing, and treatment plan with your veterinarian. ScriptUnlock connects pet owners to verified pharmacies; we do not provide veterinary advice.