Osteoarthritis in Cats
Feline OA affects 40-90% of senior cats but is under-diagnosed. Treatment combines weight management, environmental modification, NSAIDs (carefully, given CKD prevalence), monoclonal antibody therapy (frunevetmab), and adjunct analgesics.
Long-term NSAID use in cats requires renal monitoring (USG, UPC, blood pressure). Avoid in IRIS stage ≥2 CKD.
Symptoms to watch for
- •Reluctance to jump up or down
- •Decreased grooming (matted coat)
- •Stiffness after rest
- •Reduced play or activity
- •House soiling (can't reach litter box comfortably)
Treatment options
Solensia — anti-NGF mAb. FDA-approved 2022. Monthly SC injection. Renal-safe.
Neuropathic pain adjunct. Xylitol-free compounded liquid.
NSAID — chronic use NOT FDA-approved in US cats (renal concerns). Used long-term in EU/AU at low dose with monitoring.
NMDA antagonist for chronic pain; compounded flavored.
Valid vet prescription required · HIPAA-compliant · Free to pet owners
FAQs — Osteoarthritis in Cats
Sources & review
Reviewed by: ScriptUnlock Pharmacy Verification Team
Last reviewed: June 2026
Sources cited:
- • AAFP/ISFM Pain Management Guidelines
- • WSAVA Pain Council
- • Frunevetmab FDA Label
This information is educational and does not substitute for veterinary advice. Always confirm diagnosis, dosing, and treatment plan with your veterinarian. ScriptUnlock connects pet owners to verified pharmacies; we do not provide veterinary advice.