Sertraline Side Effects
Common and serious side effects of Sertraline (Sertraline Hydrochloride) — what to expect and how to manage them.
Common Side Effects
- Nausea (especially first 1-2 weeks)
- Diarrhea
- Dry mouth
- Insomnia or drowsiness
- Sexual dysfunction (decreased libido, delayed orgasm — up to 30%)
- Sweating
- Tremor
- Headache
Serious Side Effects
Seek immediate care if severe- Suicidal thoughts or behaviors (BLACK BOX WARNING: monitor closely in patients <25, especially weeks 1-4)
- Serotonin syndrome (with MAOIs, triptans, tramadol, other serotonergic drugs — fever, agitation, rapid heart rate)
- Bleeding risk (especially with NSAIDs, aspirin, warfarin)
- Hyponatremia (low sodium — especially elderly)
- Discontinuation syndrome if stopped abruptly (dizziness, "brain zaps", flu-like symptoms)
Managing Side Effects
- Full antidepressant effect takes 4-6 weeks — do not stop early
- Never stop abruptly — taper slowly over weeks or months
- Take in the morning if causing insomnia; at night if causing drowsiness
- GI side effects improve significantly after 1-2 weeks
- Sexual side effects: talk to your doctor — dose adjustment or addition of bupropion may help
What Your Doctor May Monitor
Mood and suicidal ideation (especially weeks 1-4 and after dose changes)Sodium levels in elderlySigns of bleedingSerotonin syndrome if combining with other serotonergic medications
Sertraline Cash Price
Sertraline cash prices start from $5 when pharmacies compete on Script Unlock — up to 80% below retail. No insurance required.
Compare Sertraline PricesMedical Disclaimer: This information is for educational reference only. Side effects vary by individual, dose, and other medications. Always consult your healthcare provider for personalized medical advice. Do not stop or change your medication without medical guidance.