Semaglutide Side Effects
Common and serious side effects of Semaglutide (Semaglutide) — what to expect and how to manage them.
Common Side Effects
- Nausea (most common, especially early)
- Diarrhea
- Vomiting
- Constipation
- Stomach pain
- Decreased appetite
- Injection site reactions (redness, itching)
Serious Side Effects
Seek immediate care if severe- Pancreatitis (severe persistent stomach pain — seek emergency care)
- Gallbladder problems including gallstones
- Kidney injury (from vomiting/dehydration)
- Thyroid C-cell tumors (contraindicated in personal/family history of medullary thyroid cancer or MEN2)
- Hypoglycemia (especially when combined with insulin or sulfonylureas)
- Allergic reactions
Managing Side Effects
- Titrate slowly — nausea improves significantly after 4-8 weeks
- Eat smaller, lower-fat meals
- Stay hydrated — dehydration worsens kidney risk
- Inject subcutaneously into abdomen, thigh, or upper arm — rotate sites weekly
- If vomiting for >24 hours, contact your doctor
What Your Doctor May Monitor
Pancreatic enzymes if abdominal painThyroid symptomsKidney functionBlood glucoseWeight and A1C
Semaglutide Cash Price
Semaglutide cash prices start from $420 when pharmacies compete on Script Unlock — up to 65% below retail. No insurance required.
Compare Semaglutide PricesMedical Disclaimer: This information is for educational reference only. Side effects vary by individual, dose, and other medications. Always consult your healthcare provider for personalized medical advice. Do not stop or change your medication without medical guidance.