Free or Low-Cost Setmelanotide — Patient Assistance Programs + Cash Options
If you can't afford Setmelanotide, you're not alone. Roughly 1 in 4 Americans skip prescriptions because of cost. Here are real options — most are free or near-free for qualifying patients.
4 paths to free or low-cost Setmelanotide
Manufacturer Patient Assistance Program (PAP)
Most major brand-name drugs offer a free-drug program for uninsured or underinsured patients who qualify by income. Examples include Pfizer RxPathways, Lilly Cares, BMS Patient Assistance Foundation, Merck Helps, and AstraZeneca AZ&Me. Approval typically takes 2–6 weeks; medication is then shipped to your prescriber or pharmacy.
340B program (community health centers)
Federally Qualified Health Centers (FQHCs) and 340B-participating community clinics dispense Setmelanotide at significantly reduced prices — often $0–$10 — for qualifying patients on a sliding income scale. Find your nearest FQHC at findahealthcenter.hrsa.gov.
State Pharmaceutical Assistance Programs (SPAP)
Many U.S. states run SPAPs for seniors, people with disabilities, and low-income residents — they help cover Setmelanotide not paid for by Medicare or insurance. Notable programs: NY EPIC, PA PACE/PACENET, NJ PAAD, MA Prescription Advantage, CT ConnPACE. Check your state department of health.
ScriptUnlock cash price — from $3825
If you don't qualify for free programs, or can't wait 2–6 weeks for PAP approval, ScriptUnlock's pharmacy bidding finds the lowest cash price for Setmelanotide — often cheaper than "discounted" programs without the paperwork, income forms, or eligibility queue.
Income eligibility guide
Most Setmelanotide assistance programs use the Federal Poverty Level (FPL) as the gate. Here's a rough sense of where you might qualify:
| Household size | 200% FPL (typical 340B) | 400% FPL (typical PAP) |
|---|---|---|
| 1 person | ~$30,120 | ~$60,240 |
| 2 people | ~$40,880 | ~$81,760 |
| 3 people | ~$51,640 | ~$103,280 |
| 4 people | ~$62,400 | ~$124,800 |
Approximate 2024 figures, 48 contiguous states. Each program sets its own thresholds — always confirm with the program directly.
Which is fastest?
- ScriptUnlock cash price — minutes
Upload, get bids, pick up same day. Setmelanotide from $3825.
- 340B / FQHC — same week
Book an appointment, qualify on sliding scale, fill at the clinic pharmacy.
- State SPAP — 2–4 weeks
Eligibility application, then enrolment, then fills. Worth it long-term.
- Manufacturer PAP — 2–6 weeks
Application + income proof + prescriber signature → free Setmelanotide delivery.
Suggested play: Use ScriptUnlock today to get Setmelanotide this week, while you apply for PAP in parallel. When PAP approves in 2–6 weeks, you switch to free.
Get Setmelanotide this week — from $3825
Verified U.S. pharmacies compete for your prescription. No card, no insurance, no membership.
Compare Setmelanotide pricesFree Setmelanotide — FAQ
Can I get Setmelanotide for free?+
Yes — qualifying patients can often get Setmelanotide for free through the manufacturer's Patient Assistance Program (PAP), 340B community health centers, or state pharmaceutical assistance programs. Eligibility typically depends on income (most programs use 200–500% of the federal poverty level), insurance status, and U.S. residency.
What is the Setmelanotide patient assistance program?+
A patient assistance program (PAP) is a free-drug program run by the manufacturer of Setmelanotide for uninsured or underinsured patients who can't afford the medication. You apply with proof of income and a prescriber signature. Approval typically takes 2–6 weeks.
How do I apply for free Setmelanotide?+
Three steps: (1) Find the manufacturer's PAP application on their website or via NeedyMeds.org. (2) Gather income proof (tax return or pay stubs) and your prescriber's signature. (3) Submit and wait 2–6 weeks. If you need Setmelanotide sooner, ScriptUnlock cash price from $3825 is available immediately.
What is the cheapest way to get Setmelanotide?+
For qualifying low-income patients, the manufacturer PAP can deliver Setmelanotide at $0. For everyone else, the cheapest immediate path is ScriptUnlock cash price from $3825 — pharmacies compete on your prescription. This is usually cheaper than GoodRx and cheaper than most insurance copays.
Is Setmelanotide available through 340B pharmacies?+
Yes — Federally Qualified Health Centers (FQHCs) and 340B-participating community health centers can dispense Setmelanotide at significantly reduced prices to qualifying patients. Find your nearest FQHC at findahealthcenter.hrsa.gov.
Setmelanotide without insurance — pay less
No insurance? No problem. Upload your Setmelanotide prescription and verified pharmacies compete on cash price.
Free for patients. No insurance, no membership, no sign-up required.