St. John's Wort Drug Interactions
St. John's Wort can interact with prescription medications, over-the-counter products, supplements, and certain foods. Most interactions are manageable when your pharmacist knows your full medication list.
Common interaction categories to flag with your pharmacist
Other prescription medications
Bring a current list of every prescription you take when filling St. John's Wort. Common interactions involve blood thinners, antibiotics, antidepressants, and pain medications.
Over-the-counter products
OTC products like NSAIDs, antacids, cold/flu remedies, and sleep aids can interact with St. John's Wort. Confirm with your pharmacist before combining.
Supplements and herbal products
Common offenders include St John's wort, garlic, ginkgo, high-dose vitamins, and mineral supplements. Disclose all supplements when filling St. John's Wort.
Foods and beverages
Grapefruit, leafy greens (vitamin K), tyramine-rich foods, and others can interact with specific medications. Ask whether any apply to St. John's Wort.
Alcohol
Alcohol interacts with many medications, sometimes seriously. See our dedicated St. John's Wort and alcohol guide.
Caffeine and stimulants
Caffeine, energy drinks, and other stimulants can interact with some St. John's Wort use cases. Check with your pharmacist if you consume regularly.
How to check $St. John's Wort interactions safely
- Give your pharmacist a complete list of everything you take — prescription, OTC, supplements, herbal.
- Update your pharmacy profile whenever you start or stop a medication.
- Use a single pharmacy when possible — the pharmacist's system flags interactions automatically.
- Read the patient information leaflet that comes with St. John's Wort.
- Call your pharmacist before starting any new product — they're trained interaction specialists.
Symptoms that suggest an interaction
Unusual drowsiness, rapid heart rate, blood pressure changes, severe GI symptoms, unusual bleeding, or any reaction that feels new — call your pharmacist or prescriber immediately.
Find the lowest St. John's Wort cash price
Upload your St. John's Wort prescription and verified pharmacies bid for your fill. 100% free for patients. No insurance, no membership, no sign-up.
Free for patients. No insurance, no membership, no sign-up required.
St. John's Wort interactions: FAQs
What medications interact with St. John's Wort?
St. John's Wort can interact with many prescription medications, OTC products, supplements, and herbal remedies. Before starting St. John's Wort, give your pharmacist a complete list of everything you take — they'll flag any clinically significant interactions.
Can I take St. John's Wort with over-the-counter medications?
Some OTC medications interact with St. John's Wort and others don't. Common ones to ask about: NSAIDs, antacids, cold/flu products, and any sleep aids. Confirm with your pharmacist before combining.
Are there supplements I should avoid while taking St. John's Wort?
Supplements and herbal products can interact with St. John's Wort — common examples include St John's wort, grapefruit-related products, and high-dose vitamins. Always disclose supplements to your pharmacist.
What should I do if I've started a new medication and I'm on St. John's Wort?
Whenever you start any new prescription, OTC, or supplement, mention St. John's Wort to the prescriber or pharmacist. Most interactions are manageable with timing changes or dose adjustments.
Where do I find the lowest cash price for St. John's Wort?
Compare cash prices across local pharmacies before filling. ScriptUnlock surfaces the lowest available for St. John's Wort among participating pharmacies.