Sertraline vs Escitalopram
Compare Sertraline (Zoloft) and Escitalopram (Lexapro) for depression and anxiety.
Head-to-Head Comparison
| Category | Sertraline | Escitalopram |
|---|---|---|
Effectiveness | Effective for depression, OCD, panic, PTSD, social anxiety | Highly effective for depression and generalized anxiety, best-tolerated SSRI |
Cost | $10-15/month generic | $10-20/month generic |
| Side Effects | Nausea, diarrhea, insomnia, sexual dysfunction | Minimal side effects, lowest discontinuation rate of all SSRIs |
Convenience | Once daily | Once daily |
| Insurance Coverage | Widely covered | Widely covered |
Key Differences
- Escitalopram has fewest drug interactions of all SSRIs
- Sertraline approved for more indications (OCD, PTSD)
- Escitalopram ranked #1 for tolerability in STAR*D trial
- Sertraline slightly more activating
Similarities
- Both are SSRIs
- Once daily dosing
- Both generic and affordable
- Similar onset (2-4 weeks)
Which Is Best For You?
Sertraline is Best For:
- OCD
- PTSD
- Patients needing broad indication coverage
- Social anxiety disorder
Escitalopram is Best For:
- GAD
- MDD with minimal side effects priority
- First-time antidepressant users
- Elderly patients
Frequently Asked Questions
Is Lexapro or Zoloft better for anxiety?
Both are effective. Escitalopram (Lexapro) is often preferred for GAD due to its tolerability profile. Sertraline (Zoloft) has broader FDA approvals including social anxiety and PTSD.
Which has fewer side effects, Sertraline or Escitalopram?
Escitalopram generally has fewer side effects and the lowest discontinuation rate among SSRIs in comparative studies.
Other Antidepressants Comparisons
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Compare Prices for Sertraline and Escitalopram
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