Head-to-Head Comparison
| Category | ibuprofen | naproxen |
|---|---|---|
Effectiveness | Fast-acting, good for acute pain and fever | Longer-lasting, better for chronic pain and inflammation |
Cost | Cheapest OTC NSAID | Slightly more expensive OTC |
| Side Effects | GI upset, kidney risk with long-term use | Lower cardiovascular risk, more GI-friendly per some studies |
Convenience | Every 4-6 hours | Every 8-12 hours — twice daily |
| Insurance Coverage | OTC, no prescription needed | OTC + prescription strength available |
Key Differences
- Naproxen lasts 8-12 hours vs 4-6 for ibuprofen
- Naproxen may have lower cardiovascular risk
- Ibuprofen faster onset
- Prescription naproxen (500mg) significantly stronger than OTC
Similarities
- Both NSAIDs
- Both reduce pain, fever, inflammation
- Both available OTC and prescription
- Both have GI risks
Which Is Best For You?
ibuprofen is Best For:
- Acute pain needing fast relief
- Fever
- Short-term use
- Children (weight-dosed)
naproxen is Best For:
- Arthritis and chronic inflammation
- Menstrual cramps
- Patients needing less frequent dosing
- Cardiovascular risk patients
Frequently Asked Questions
Is ibuprofen or naproxen better for arthritis?
Naproxen is often preferred for arthritis due to its longer duration of action, reducing dosing frequency. Prescription-strength naproxen 500mg is very effective.
Can I take ibuprofen and naproxen together?
No. Never combine two NSAIDs — this significantly increases risk of GI bleeding and kidney damage without added benefit.
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