Anticoagulants
Apixaban vs Rivaroxaban
Compare Apixaban (Eliquis) and Rivaroxaban (Xarelto) for AFib and clot prevention.
Head-to-Head Comparison
| Category | Apixaban | Rivaroxaban |
|---|---|---|
Effectiveness | Slightly lower bleeding rates in studies | Equivalent stroke prevention in AFib |
Cost | Generics ~$30-80/month | Generics ~$25-70/month |
| Side Effects | Twice daily dosing reduces peak drug levels | Once daily dosing, higher peak levels |
Convenience | Twice daily | Once daily with evening meal |
| Insurance Coverage | Covered most plans | Covered most plans |
Key Differences
- Rivaroxaban once daily; Apixaban twice daily
- Apixaban shows lower GI bleeding in trials
- Rivaroxaban must be taken with food
- Apixaban has dedicated reversal agent (Andexxa)
Similarities
- Both Factor Xa inhibitors (DOACs)
- No monitoring required
- Both used in AFib, DVT, PE
- Both available as generics
Which Is Best For You?
Apixaban is Best For:
- Patients with prior GI bleeding history
- Higher bleeding risk patients
- When twice daily dosing is acceptable
Rivaroxaban is Best For:
- Patients preferring once daily dosing
- DVT/PE treatment
- Lower cost priority
Frequently Asked Questions
Is Eliquis or Xarelto better?
Both are excellent DOACs. Apixaban shows marginally lower bleeding in studies; Rivaroxaban offers once-daily convenience. Guidelines consider them therapeutically equivalent for most patients.
Which is cheaper, Eliquis or Xarelto?
Both now have generics available. Compare real pharmacy prices on Script Unlock — pharmacies compete and prices vary significantly.
Other Anticoagulants Comparisons
Compare Prices for Apixaban and Rivaroxaban
No matter which medication you choose, Script Unlock helps you find the best price from verified pharmacies. Save up to 80% on your prescriptions.
Get Your Price Quotes