Cheapest Esketamine Near You: From $723 — Compare All Pharmacies
Esketamine (Esketamine Hydrochloride) doesn't have one "cheapest" price — it has dozens, depending on which pharmacy fills it. Script Unlock makes every verified pharmacy in your area bid on your script so you see the lowest price head-to-head.
Upload your Rx — every verified pharmacy in your zip code competes for the fill.
Why the same Esketamine costs $723 at one pharmacy and $850 at another
It's the same FDA-approved Esketamine Hydrochloride from the same wholesalers, sitting on different pharmacy shelves with vastly different markups. The price spread on Esketamine between the cheapest and most expensive pharmacy in a typical US city is ~$212 per month — that's $2544/year for the exact same medication.
Three drivers cause the spread: (1) chain pharmacies use opaque national list prices, (2) independents compete on cash-pay because they have to, and (3) PBM contracts at chains inflate cash prices to protect rebate economics. None of this benefits you. Bidding does.
Esketamine Price by Pharmacy Type
Typical monthly cash prices for Esketamine across the five main pharmacy types in 2026:
| Pharmacy Type | Typical Esketamine Price | Best For |
|---|---|---|
| Big Chain (CVS, Walgreens, Rite-Aid) | ~$935/mo | Convenience, 24-hr locations |
| Grocery Chain (Kroger, Walmart, Costco) | ~$680/mo | Low common generics, one-stop shopping |
| Independent Pharmacy | ~$425/mo | Cash-pay savings, personal service |
| Compounding Pharmacy | Varies | Custom dosage, allergen-free formulations |
| Script Unlock | From $723/mo | Lowest verified price (all types compete) |
Prices are typical 2026 monthly cash prices for Esketamine (Esketamine Hydrochloride) at common dosages. Actual price depends on zip code, quantity, and live bids.
Know Your Pharmacy Options
Big Chain
Convenient, but highest markup on Esketamine. Use only if you need 24-hr or specialty support.
Grocery / Big Box
Walmart, Kroger, Costco — solid mid-tier pricing on generics like Esketamine Hydrochloride.
Independent
Usually the cheapest cash-pay for Esketamine. Personal service and aggressive bidding.
Compounding
Custom strength, dye-free, allergen-free, alternative dosage forms when needed.
How to Find the Cheapest Esketamine Near You
Don't trust a single coupon site
GoodRx, SingleCare, and RxSaver all show different prices for the same Esketamine script — and none reflect what an independent pharmacy would actually charge in a bidding situation.
Upload your prescription to Script Unlock
Snap a photo of your Esketamine Rx. Verified pharmacies in your zip code start bidding within minutes. No signup wall.
Compare bids — not just price, but distance & pickup time
The cheapest Esketamine bid sometimes comes from a pharmacy 8 miles away. A bid $2 higher next door might be the smarter choice.
Lock in the bid and pick up
Accept the bid you like. We coordinate the e-script transfer. Pick up your Esketamine the same day at the locked price.
Cheapest Esketamine by City
Top US metros with active competitive bidding for Esketamine:
- New YorkNew York · From $723
- Los AngelesCalifornia · From $723
- ChicagoIllinois · From $723
- HoustonTexas · From $723
- PhoenixArizona · From $723
- PhiladelphiaPennsylvania · From $723
- San AntonioTexas · From $723
- San DiegoCalifornia · From $723
- DallasTexas · From $723
- San JoseCalifornia · From $723
- AustinTexas · From $723
- JacksonvilleFlorida · From $723
- Fort WorthTexas · From $723
- ColumbusOhio · From $723
- CharlotteNorth Carolina · From $723
- San FranciscoCalifornia · From $723
- IndianapolisIndiana · From $723
- SeattleWashington · From $723
- DenverColorado · From $723
- WashingtonDistrict of Columbia · From $723
Frequently Asked Questions
What is the cheapest pharmacy for Esketamine?+
It depends on your zip code. In most metros, independent pharmacies on Script Unlock submit the lowest bids for Esketamine (~$425/mo), beating CVS, Walgreens, and Rite-Aid by a wide margin. The only reliable way to find the cheapest is to let verified pharmacies bid — current low bids start at $723/mo.
Why is Esketamine so much cheaper at one pharmacy than another?+
Three reasons: (1) chain pharmacies use national list prices that include overhead from corporate marketing; (2) independent pharmacies have lower overhead and use cash-pay pricing as a competitive weapon; (3) PBM contracts at chains inflate the published cash price to maintain rebate spreads. Same FDA-approved Esketamine, different markup.
Is Walmart or Costco cheaper for Esketamine?+
Sometimes. Walmart and Costco have aggressive generic programs that often beat CVS/Walgreens on common drugs like Esketamine. But independent pharmacies on Script Unlock typically still come in lower (~$425/mo) because they bid against each other in real time, and you don't need a Costco membership.
Can a compounding pharmacy fill Esketamine cheaper?+
Sometimes — particularly if you need a non-standard strength, a different dosage form (capsule vs tablet, liquid vs solid), or a single-ingredient version without unwanted excipients. Compounding pharmacies on Script Unlock bid alongside retail pharmacies so you see all options head-to-head.
How do I know I'm getting the actual cheapest Esketamine price?+
Because verified pharmacies bid against each other on your specific prescription — there's no "list price" to game. The lowest bid wins. Script Unlock displays every bid transparently, including pharmacy name, distance, and pickup time, so you can confirm you're paying the lowest verified Esketamine price near you.
More Esketamine Resources
Find the cheapest Esketamine — verified, in minutes
Upload your prescription. Every verified pharmacy in your zip code bids. You pay the lowest verified price — currently from $723/month.
Find Cheapest Esketamine