Cheapest Pharmacies in South Dakota (2026)
With 9.4% of South Dakota residents uninsured, finding the cheapest pharmacy matters. Here's what the data shows — and how to always pay the lowest price in South Dakota.
What We Know About South Dakota Pharmacy Prices
- Independent pharmacies in South Dakota charge an average of 30-50% less than chains for the same generic medication
- Compounding pharmacies in South Dakota offer the most competitive pricing for specialty formulations
- Script Unlock creates real competition — South Dakota pharmacies bid to win your prescription rather than using pre-set prices
- Cash pay at Script Unlock often beats South Dakota insurance copays — especially pre-deductible
Pharmacy Types in South Dakota — Ranked by Average Price
Independent Pharmacies
No corporate overhead, community pricing, direct competition
30-50% below chain prices
Compounding Pharmacies
Prepare medications from scratch, no brand markup
Custom pricing — often 40-70% below brand
Script Unlock Network
Real-time bidding — pharmacies compete for your prescription
Average 9.4% below retail
Chain Pharmacies
Convenient but rarely the cheapest option
Retail price — starting point, not ending point