Rybelsus Alternatives in South Carolina
Compare generic and therapeutic alternatives to Rybelsus (semaglutide (oral)) available at South Carolina pharmacies. Save up to 32% on your prescription — no insurance required.
Top Alternatives in South Carolina
Ozempic (injectable semaglutide)
therapeutic
Same molecule, weekly injection — comparable glycaemic and weight outcomes
Avg cash price: $940/mo
Metformin
therapeutic
First-line T2D oral medication — tiny fraction of the cost
Avg cash price: $8/mo
Dulaglutide (Trulicity)
therapeutic
Weekly GLP-1 injection — similar efficacy, similar price
Avg cash price: $870/mo
South Carolina Prescription Assistance Programs
South Carolina Medicaid Rx (Healthy Connections)
Prescription drug coverage for South Carolina Medicaid (Healthy Connections) beneficiaries.
Eligibility: Low-income South Carolina children, pregnant women, seniors, and people with disabilities. South Carolina has not expanded Medicaid, limiting adult coverage.
Frequently Asked Questions
What makes Rybelsus different from Ozempic?
Rybelsus is an oral tablet taken daily, while Ozempic is a weekly subcutaneous injection. Both contain semaglutide. Rybelsus avoids injections but has slightly lower bioavailability and must be taken on an empty stomach with a small sip of water.
Does Rybelsus cause weight loss like Ozempic?
Rybelsus produces modest weight loss of 3–5 kg in trials — less than injectable semaglutide at higher doses. It is approved for T2D glucose control, not weight loss per se.
Can I take Rybelsus with food?
No — Rybelsus must be taken fasting (nothing by mouth except up to 120 mL of plain water) for at least 30 minutes before eating, drinking, or other medications. Food severely reduces its absorption.
Is there a generic for Rybelsus?
No — Rybelsus remains under patent as of 2025. Generic oral semaglutide is not expected until the late 2020s. At ~$870/month, it is expensive without insurance coverage.
Can Script Unlock help reduce the cost of Rybelsus?
While there is no generic, Script Unlock pharmacies compete on brand pricing and may offer lower cash prices than chain pharmacies. Post your prescription to compare available bids.