Rybelsus Alternatives in Ohio
Compare generic and therapeutic alternatives to Rybelsus (semaglutide (oral)) available at Ohio pharmacies. Save up to 32% on your prescription — no insurance required.
Top Alternatives in Ohio
Ozempic (injectable semaglutide)
therapeutic
Same molecule, weekly injection — comparable glycaemic and weight outcomes
Avg cash price: $940/mo
Metformin
therapeutic
First-line T2D oral medication — tiny fraction of the cost
Avg cash price: $8/mo
Dulaglutide (Trulicity)
therapeutic
Weekly GLP-1 injection — similar efficacy, similar price
Avg cash price: $870/mo
Ohio Prescription Assistance Programs
Ohio Medicaid Rx (OhioMHAS)
Prescription drug coverage for Ohio Medicaid (MyCare Ohio, Medicaid Managed Care) beneficiaries.
Eligibility: Low-income Ohio adults, children, pregnant women, seniors, and people with disabilities. Ohio expanded Medicaid under the ACA.
Ohio Best Rx (State Discount Card)
State-sponsored prescription discount card providing savings of 10–75% on brand and generic medications at participating pharmacies.
Eligibility: All Ohio residents regardless of age or income. No enrollment required. Available at ohiobestrx.com.
Frequently Asked Questions
What makes Rybelsus different from Ozempic?
Rybelsus is an oral tablet taken daily, while Ozempic is a weekly subcutaneous injection. Both contain semaglutide. Rybelsus avoids injections but has slightly lower bioavailability and must be taken on an empty stomach with a small sip of water.
Does Rybelsus cause weight loss like Ozempic?
Rybelsus produces modest weight loss of 3–5 kg in trials — less than injectable semaglutide at higher doses. It is approved for T2D glucose control, not weight loss per se.
Can I take Rybelsus with food?
No — Rybelsus must be taken fasting (nothing by mouth except up to 120 mL of plain water) for at least 30 minutes before eating, drinking, or other medications. Food severely reduces its absorption.
Is there a generic for Rybelsus?
No — Rybelsus remains under patent as of 2025. Generic oral semaglutide is not expected until the late 2020s. At ~$870/month, it is expensive without insurance coverage.
Can Script Unlock help reduce the cost of Rybelsus?
While there is no generic, Script Unlock pharmacies compete on brand pricing and may offer lower cash prices than chain pharmacies. Post your prescription to compare available bids.