Omeprazole Alternatives in North Carolina
Compare generic and therapeutic alternatives to Omeprazole (omeprazole) available at North Carolina pharmacies. Save up to 92% on your prescription — no insurance required.
Top Alternatives in North Carolina
Pantoprazole (generic Protonix)
therapeutic
Prescription PPI — slightly fewer drug interactions than omeprazole
Avg cash price: $8/mo
Esomeprazole (generic Nexium)
therapeutic
S-enantiomer of omeprazole — marginally longer duration
Avg cash price: $15/mo
Famotidine (generic Pepcid)
therapeutic
H2 blocker — OTC alternative, weaker acid suppression
Avg cash price: $8/mo
North Carolina Prescription Assistance Programs
NC Medicaid Rx
Prescription drug coverage for NC Medicaid and NC Health Choice (CHIP) beneficiaries.
Eligibility: Low-income North Carolina adults, children, pregnant women, seniors, and people with disabilities. North Carolina expanded Medicaid in December 2023.
Frequently Asked Questions
Is omeprazole the same as Prilosec?
Yes — omeprazole is the generic name for Prilosec. It is available both OTC and by prescription and typically costs $8–$15/month. Brand Prilosec OTC is the same drug at higher cost.
What is the difference between omeprazole and pantoprazole?
Both are PPIs with similar efficacy. Pantoprazole has fewer drug interactions (does not inhibit CYP2C19 as strongly), making it preferred for patients on clopidogrel (Plavix) or certain antidepressants.
Can I take omeprazole every day long-term?
Long-term daily PPI use raises modest risks: reduced B12, magnesium, and calcium absorption; slight increased fracture risk; and possible C. difficile susceptibility. Use the lowest effective dose for the shortest necessary duration.
Is omeprazole stronger than famotidine (Pepcid)?
Yes — PPIs like omeprazole provide more complete and sustained acid suppression than H2 blockers like famotidine. PPIs are preferred for GERD and ulcer healing; H2 blockers may suffice for mild heartburn.
What does omeprazole cost through Script Unlock?
Omeprazole is available OTC without a prescription for around $10–$15/month. Prescription-strength versions through Script Unlock pharmacies may offer even lower cash pricing.