Omeprazole Alternatives in Massachusetts
Compare generic and therapeutic alternatives to Omeprazole (omeprazole) available at Massachusetts pharmacies. Save up to 92% on your prescription — no insurance required.
Top Alternatives in Massachusetts
Pantoprazole (generic Protonix)
therapeutic
Prescription PPI — slightly fewer drug interactions than omeprazole
Avg cash price: $8/mo
Esomeprazole (generic Nexium)
therapeutic
S-enantiomer of omeprazole — marginally longer duration
Avg cash price: $15/mo
Famotidine (generic Pepcid)
therapeutic
H2 blocker — OTC alternative, weaker acid suppression
Avg cash price: $8/mo
Massachusetts Prescription Assistance Programs
MassHealth (Massachusetts Medicaid)
Comprehensive prescription drug coverage for MassHealth enrollees including generics and formulary brand-name drugs.
Eligibility: Low-income Massachusetts residents: adults up to 138% FPL, seniors through Senior Care Options, children and pregnant women at higher thresholds.
Prescription Advantage (Historical Reference)
Was a state-funded pharmaceutical assistance program for elderly and disabled Massachusetts residents not covered by Medicare.
Eligibility: PROGRAM DISCONTINUED approximately 2014. Former participants were transitioned to Medicare Part D and MassHealth. Contact the Massachusetts Executive Office of Elder Affairs at 617-727-7750 for current alternatives.
Frequently Asked Questions
Is omeprazole the same as Prilosec?
Yes — omeprazole is the generic name for Prilosec. It is available both OTC and by prescription and typically costs $8–$15/month. Brand Prilosec OTC is the same drug at higher cost.
What is the difference between omeprazole and pantoprazole?
Both are PPIs with similar efficacy. Pantoprazole has fewer drug interactions (does not inhibit CYP2C19 as strongly), making it preferred for patients on clopidogrel (Plavix) or certain antidepressants.
Can I take omeprazole every day long-term?
Long-term daily PPI use raises modest risks: reduced B12, magnesium, and calcium absorption; slight increased fracture risk; and possible C. difficile susceptibility. Use the lowest effective dose for the shortest necessary duration.
Is omeprazole stronger than famotidine (Pepcid)?
Yes — PPIs like omeprazole provide more complete and sustained acid suppression than H2 blockers like famotidine. PPIs are preferred for GERD and ulcer healing; H2 blockers may suffice for mild heartburn.
What does omeprazole cost through Script Unlock?
Omeprazole is available OTC without a prescription for around $10–$15/month. Prescription-strength versions through Script Unlock pharmacies may offer even lower cash pricing.