Metformin Alternatives in Minnesota
Compare generic and therapeutic alternatives to Metformin (metformin hydrochloride) available at Minnesota pharmacies. Save up to 90% on your prescription — no insurance required.
Top Alternatives in Minnesota
Empagliflozin (Jardiance)
therapeutic
SGLT2 inhibitor with cardiovascular / renal benefit — add-on for high-risk patients
Avg cash price: $560/mo
Semaglutide (Ozempic)
therapeutic
GLP-1 agonist — superior weight loss, added if metformin insufficient
Avg cash price: $940/mo
Glipizide (sulfonylurea)
therapeutic
Older oral diabetes drug — affordable but causes weight gain and hypoglycaemia
Avg cash price: $10/mo
Minnesota Prescription Assistance Programs
Minnesota Medicaid (Medical Assistance)
Prescription drug coverage for Medical Assistance (Medicaid) and MinnesotaCare enrollees.
Eligibility: Low-income Minnesota adults, children, pregnant women, seniors, and people with disabilities meeting income guidelines.
Minnesota Rx Connect
Online resource that connects Minnesota residents to pharmaceutical manufacturer patient assistance programs and other prescription savings programs.
Eligibility: Minnesota residents of all ages who need help affording prescription medications. Available at rxconnect.mn.gov.
Frequently Asked Questions
Why is metformin still the first-line drug for type 2 diabetes?
Metformin has 60+ years of safety data, lowers HbA1c effectively, does not cause hypoglycaemia or weight gain, reduces cardiovascular risk, and costs under $10/month as a generic.
What is metformin ER and is it better than regular metformin?
Metformin extended-release (ER/XR) is taken once daily and causes less GI side effects (nausea, diarrhoea) than immediate-release. Most patients who struggle with regular metformin tolerate ER well.
Does metformin cause B12 deficiency?
Yes — long-term metformin use reduces vitamin B12 absorption in ~30% of patients. Annual B12 testing is recommended, especially for patients on metformin for >4 years or those with neuropathy.
Can metformin be used for PCOS without diabetes?
Yes — metformin is used off-label in PCOS to improve insulin sensitivity, regulate menstrual cycles, and reduce androgen levels. It is often combined with lifestyle change and hormonal therapy.
What does metformin cost through Script Unlock?
Metformin is one of the cheapest medications in existence — typically $4–$10/month. Script Unlock pharmacies offer competitive cash pricing and can supply both IR and ER formulations.