Duloxetine Alternatives in California
Compare generic and therapeutic alternatives to Duloxetine (duloxetine) available at California pharmacies. Save up to 90% on your prescription — no insurance required.
Top Alternatives in California
Sertraline (generic Zoloft)
therapeutic
SSRI — similar antidepressant efficacy, slightly cheaper
Avg cash price: $10/mo
Venlafaxine (generic Effexor)
therapeutic
Older SNRI — comparable to duloxetine, very affordable as generic
Avg cash price: $15/mo
Pregabalin (generic Lyrica)
therapeutic
For neuropathic pain — alternative to duloxetine in nerve pain
Avg cash price: $40/mo
California Prescription Assistance Programs
Medi-Cal Rx
Comprehensive outpatient prescription drug coverage for Medi-Cal beneficiaries, including generic and brand-name medications on the formulary.
Eligibility: California Medicaid (Medi-Cal) enrollees. Income limits vary by category; generally up to 138% FPL for adults.
GHPP (Genetically Handicapped Persons Program)
Prescription drugs and medical services for individuals with covered genetic conditions including cystic fibrosis, hemophilia, PKU, sickle cell disease, and others.
Eligibility: California residents with a diagnosed covered genetic condition; income-based co-pays apply.
Frequently Asked Questions
Is duloxetine the same as Cymbalta?
Yes — duloxetine is the generic form of Cymbalta. It has been available as a generic since 2013 and costs $15–$25/month versus $200+ for brand Cymbalta.
What is duloxetine most commonly prescribed for?
Duloxetine is used for depression, generalised anxiety disorder, diabetic peripheral neuropathy, fibromyalgia, and chronic musculoskeletal pain — making it one of the most versatile generics available.
How does duloxetine compare to sertraline for depression?
Both are effective antidepressants. Duloxetine (SNRI) targets both serotonin and norepinephrine; sertraline (SSRI) primarily targets serotonin. Duloxetine may have an edge for patients with comorbid pain.
Does duloxetine help with nerve pain?
Yes — duloxetine is FDA-approved for diabetic peripheral neuropathy and fibromyalgia. It is a first-line agent for neuropathic pain alongside gabapentin and pregabalin.
What does duloxetine cost through Script Unlock?
Generic duloxetine is typically $12–$22/month. Script Unlock pharmacies frequently offer competitive cash pricing for this popular generic.